Interleukin-20 receptor: Difference between revisions
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'''Interleukin 20 [[receptors]]''' ('''IL20R''') belong to the [[IL-10 family]]. IL20R are involved in both [[pro-inflammatory]] and anti-inflammatory immune response.<ref>{{Cite journal |last=Rutz |first=Sascha |last2=Wang |first2=Xiaoting |last3=Ouyang |first3=Wenjun |date=2014-11-25 |title=The IL-20 subfamily of cytokines — from host defence to tissue homeostasis |url=http://dx.doi.org/10.1038/nri3766 |journal=Nature Reviews Immunology |volume=14 |issue=12 |pages=783–795 |doi=10.1038/nri3766 |issn=1474-1733}}</ref><ref name=":1">{{Cite journal |last=Kragstrup |first=Tue W. |last2=Andersen |first2=Thomas |last3=Heftdal |first3=Line D. |last4=Hvid |first4=Malene |last5=Gerwien |first5=Jens |last6=Sivakumar |first6=Pallavur |last7=Taylor |first7=Peter C. |last8=Senolt |first8=Ladislav |last9=Deleuran |first9=Bent |date=2018-09-25 |title=The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis |url=http://dx.doi.org/10.3389/fimmu.2018.02226 |journal=Frontiers in Immunology |volume=9 |doi=10.3389/fimmu.2018.02226 |issn=1664-3224}}</ref> There are two types of IL20R: Type I and Type II. |
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'''Interleukin-20 receptor''' is a [[type II cytokine receptor]]. It is a heterodimer of [[interleukin 20 receptor, alpha subunit|α]] and [[interleukin 20 receptor, beta subunit|β]] subunits.<ref name="pmid11163236">{{cite journal |vauthors=Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA | title = Interleukin 20: discovery, receptor identification, and role in epidermal function | journal = Cell | volume = 104 | issue = 1 | pages = 9–19 | year = 2001 | pmid = 11163236 | doi = 10.1016/S0092-8674(01)00187-8 | s2cid = 7460710 | doi-access = free }}</ref> |
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IL20R is found in many organ resident [[Effector cell|effector cells]] such as [[Keratinocyte|keratinocytes]] at the [[Epidermis|skin epidermis]], [[Osteoclast|osteoclasts]], found in bones, and [[Epithelium|epithelial cells]] of the [[Gastrointestinal tract|intestine]] and [[trachea]]. IL20R alpha and beta subunits have also been found in some immune cells.<ref name=":1" /> IL20R is implicated in diseases such as [[psoriasis]], [[rheumatoid arthritis]], and [[glaucoma]]. |
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== Structure and function == |
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There are two types of IL20R: Type I, made up of the [[Interleukin 20 receptor, alpha subunit|IL-20 receptor alpha subunit]] and [[Interleukin 20 receptor, beta subunit|beta subunit]], and Type II, made up of the [[Interleukin-22 receptor|IL-22 receptor]] and IL-20 receptor beta subunit.<ref name=":0">{{Cite journal |last=Wegenka |first=Ursula Maria |date=2010-10-01 |title=IL-20: Biological functions mediated through two types of receptor complexes |url=https://www.sciencedirect.com/science/article/pii/S1359610110000596 |journal=Cytokine & Growth Factor Reviews |series=IL-10 Family of Cytokines |language=en |volume=21 |issue=5 |pages=353–363 |doi=10.1016/j.cytogfr.2010.08.001 |issn=1359-6101}}</ref> Both types of receptor bind the [[Cytokine|cytokines]] [[Interleukin 20|IL-20]], [[Interleukin 24|IL-24]]. Type 1 also binds cytokine [[Interleukin 19|IL-19]].<ref name=":2">{{Cite web |last=Chen |first=Jun |last2=Caspi |first2=Rachel R |last3=Po Chong |first3=Wai |title=IL-20 receptor cytokines in autoimmune diseases |url=https://academic.oup.com/jleukbio/article/104/5/953/6935471 |access-date=2023-03-10 |website=academic.oup.com |doi=10.1002/jlb.mr1117-471r |pmc=PMC6298946 |pmid=30260500}}</ref><ref>{{Cite journal |last=Ouyang |first=Wenjun |last2=O’Garra |first2=Anne |date=2019-04-16 |title=IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation |url=https://www.sciencedirect.com/science/article/pii/S1074761319301372 |journal=Immunity |language=en |volume=50 |issue=4 |pages=871–891 |doi=10.1016/j.immuni.2019.03.020 |issn=1074-7613}}</ref> |
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==References== |
==References== |
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Revision as of 17:30, 10 March 2023
| interleukin 20 receptor, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL20RA | ||||||
| Alt. symbols | ZCYTOR7, IL-20R1 | ||||||
| NCBI gene | 53832 | ||||||
| HGNC | 6003 | ||||||
| OMIM | 605620 | ||||||
| RefSeq | NM_014432 | ||||||
| UniProt | Q9UHF4 | ||||||
| Other data | |||||||
| Locus | Chr. 6 q23.3 | ||||||
| |||||||
| interleukin 20 receptor beta | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL20RB | ||||||
| Alt. symbols | FNDC6 | ||||||
| NCBI gene | 53833 | ||||||
| HGNC | 6004 | ||||||
| OMIM | 605621 | ||||||
| RefSeq | NM_144717 | ||||||
| UniProt | Q6UXL0 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q22.3 | ||||||
| |||||||
Interleukin 20 receptors (IL20R) belong to the IL-10 family. IL20R are involved in both pro-inflammatory and anti-inflammatory immune response.[1][2] There are two types of IL20R: Type I and Type II.
IL20R is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20R alpha and beta subunits have also been found in some immune cells.[2] IL20R is implicated in diseases such as psoriasis, rheumatoid arthritis, and glaucoma.
Structure and function
There are two types of IL20R: Type I, made up of the IL-20 receptor alpha subunit and beta subunit, and Type II, made up of the IL-22 receptor and IL-20 receptor beta subunit.[3] Both types of receptor bind the cytokines IL-20, IL-24. Type 1 also binds cytokine IL-19.[4][5]
References
- ^ Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (2014-11-25). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1733.
- ^ a b Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101.
- ^ Chen, Jun; Caspi, Rachel R; Po Chong, Wai. "IL-20 receptor cytokines in autoimmune diseases". academic.oup.com. doi:10.1002/jlb.mr1117-471r. PMC 6298946. PMID 30260500. Retrieved 2023-03-10.
{{cite web}}: CS1 maint: PMC format (link) - ^ Ouyang, Wenjun; O’Garra, Anne (2019-04-16). "IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation". Immunity. 50 (4): 871–891. doi:10.1016/j.immuni.2019.03.020. ISSN 1074-7613.
External links
- Receptors,+Interleukin-20 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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