Interleukin-10 receptor
| interleukin 10 receptor, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL10RA | ||||||
| Alt. symbols | IL10R | ||||||
| NCBI gene | 3587 | ||||||
| HGNC | 5964 | ||||||
| OMIM | 146933 | ||||||
| RefSeq | NM_001558 | ||||||
| UniProt | Q13651 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q23 | ||||||
| |||||||
| interleukin 10 receptor, beta | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL10RB | ||||||
| Alt. symbols | CRFB4, D21S58, D21S66 | ||||||
| NCBI gene | 3588 | ||||||
| HGNC | 5965 | ||||||
| OMIM | 123889 | ||||||
| RefSeq | NM_000628 | ||||||
| UniProt | Q08334 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q22.1-22.2 | ||||||
| |||||||
Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α[1] and 2β[2] subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.
References
- ^ Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391.
- ^ Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220. PMID 9312047.
External links
- Receptors,+Interleukin-10 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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