From Wikipedia, the free encyclopedia
  • 3-(3-ethylimidazol-4-yl)-5-iodo-1H-indole
PubChem CID
Chemical and physical data
Molar mass337.164 g·mol−1
3D model (JSmol)
  • CCn1cncc1-c1c[nH]c2ccc(I)cc12

AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT7 serotonin receptor.[1] AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets. AGH-107 was found to reverse the impairment in novel object recognition caused by MK-801 in mice. The relatively short half-life in rodents inhibited its use as a molecular probe.

See also[edit]


  1. ^ Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC 5431432. PMID 28473721.