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Revision as of 06:14, 14 August 2016 by Boghog(talk | contribs)(consistent citation formatting and removed further reading citations that are not specific to this gene)
The SLC10A2 (solute carrier family 10 member 2) gene in humans encodes the bile acid:sodium symporter known as the apical sodium–bile acid transporter (ASBT) or as the ileal bile acid transporter (IBAT).[5][6]
ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.[7]
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Further reading
Shneider BL (April 2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology". Journal of Pediatric Gastroenterology and Nutrition. 32 (4): 407–17. doi:10.1097/00005176-200104000-00002. PMID11396803.
Wong MH, Oelkers P, Dawson PA (November 1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity". The Journal of Biological Chemistry. 270 (45): 27228–34. doi:10.1074/jbc.270.45.27228. PMID7592981.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA (January 1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter". The American Journal of Physiology. 274 (1 Pt 1): G157-69. PMID9458785.
Montagnani M, Love MW, Rössel P, Dawson PA, Qvist P (October 2001). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption". Scandinavian Journal of Gastroenterology. 36 (10): 1077–80. doi:10.1080/003655201750422693. PMID11589382.
Love MW, Craddock AL, Angelin B, Brunzell JD, Duane WC, Dawson PA (December 2001). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (12): 2039–45. doi:10.1161/hq1201.100262. PMID11742882.
Jung D, Fried M, Kullak-Ublick GA (August 2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha". The Journal of Biological Chemistry. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID12055195.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Neimark E, Chen F, Li X, Shneider BL (July 2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter". Hepatology. 40 (1): 149–56. doi:10.1002/hep.20295. PMID15239098.
Xia X, Roundtree M, Merikhi A, Lu X, Shentu S, Lesage G (October 2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes". The Journal of Biological Chemistry. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID15304498.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Zhang EY, Phelps MA, Banerjee A, Khantwal CM, Chang C, Helsper F, Swaan PW (September 2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry. 43 (36): 11380–92. doi:10.1021/bi049270a. PMID15350125.
Banerjee A, Ray A, Chang C, Swaan PW (June 2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry. 44 (24): 8908–17. doi:10.1021/bi050553s. PMID15952798.
Nakahara M, Furuya N, Takagaki K, Sugaya T, Hirota K, Fukamizu A, Kanda T, Fujii H, Sato R (December 2005). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine". The Journal of Biological Chemistry. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID16230354.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bergheim I, Harsch S, Mueller O, Schimmel S, Fritz P, Stange EF (January 2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". Journal of Lipid Research. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID16237211.{{cite journal}}: CS1 maint: unflagged free DOI (link)