Spermine oxidase
| Spermine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.3.16 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Spermine oxidase (EC 1.5.3.16, PAOh1/SMO, AtPAO1, AtPAO4, SMO) is an enzyme with system name spermidine:oxygen oxidoreductase (spermidine-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- spermine + O2 + H2O spermidine + 3-aminopropanal + H2O2
The enzyme from Arabidopsis thaliana oxidizes norspermine to norspermidine.
References
- ^ Murray-Stewart, T., Wang, Y., Goodwin, A., Hacker, A., Meeker, A. and Casero, R.A., Jr. (2008). "Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology". FEBS J. 275 (11): 2795–2806. doi:10.1111/j.1742-4658.2008.06419.x. PMID 18422650.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Cervelli, M., Polticelli, F., Federico, R. and Mariottini, P. (2003). "Heterologous expression and characterization of mouse spermine oxidase". J. Biol. Chem. 278: 5271–5276. doi:10.1074/jbc.M207888200. PMID 12458219.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Tavladoraki, P., Rossi, M.N., Saccuti, G., Perez-Amador, M.A., Polticelli, F., Angelini, R. and Federico, R. (2006). "Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion". Plant Physiol. 141 (4): 1519–1532. doi:10.1104/pp.106.080911. PMC 1533960. PMID 16778015.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P.M. and Casero, R.A., Jr. (2003). "Properties of purified recombinant human polyamine oxidase, PAOh1/SMO". Biochem. Biophys. Res. Commun. 304: 605–611. doi:10.1016/S0006-291X(03)00636-3. PMID 12727196.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Spermine+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)