N1-Methyl-lysergic acid diethylamide

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N1-Methyl-lysergic acid diethylamide
Systematic (IUPAC) name
Clinical data
Legal status
Routes Oral
Pharmacokinetic data
Metabolism hepatic
Excretion renal
CAS number 4238-85-1 YesY
ATC code ?
PubChem CID 165200
ChemSpider 144824 YesY
Synonyms MLD-41, N1- Methyl- Lysergic Acid Diethylamide
Chemical data
Formula C21H27N3O 
Molecular mass 337.47 g/mol
 YesY (what is this?)  (verify)

N1-Methyl-lysergic acid diethylamide (MLD-41) is a derivative of LSD. The 1-methyl homologue of LSD has more of somatic than sensory effect, has fewer visuals and is less well accepted than LSD, with the range of dosages being from 100 to 300 micrograms. This indicates that it is perhaps a third the potency of LSD which is in accord with both pupillary dilation and reflex action. However, the cardiovascular responses are actually increased. Besides being less potent than LSD, it appears to have a slower onset but it is equally long lived. There is cross-tolerance between MLD-41 and LSD. Hepatic N-demethylation of MLD-41 (1-methyl-LSD)--producing the parent compound in vivo as a metabolite—may account for both the reduced potency and protracted onset of MLD-41 as a psychedelic. That is, the psychedelic activity of MLD-41 may be partially (or even entirely) due to the formation of LSD as an active metabolite.[citation needed] Metabolism of other 1-methylated-ergoloids to their secondary amine derivatives has been frequently noted in mammals.[1]


  1. ^ Müller-Schweinitzer and Tapparelli (1986). Methylergometrine, an active metabolite of methysergide. Cephalalgia. 6: 35-41.