SLC22A7: Difference between revisions

SLC22A7
Identifiers
Aliases	SLC22A7, NLT, OAT2, solute carrier family 22 member 7, hOAT11
External IDs	OMIM: 604995; MGI: 1859559; HomoloGene: 21328; GeneCards: SLC22A7; OMA:SLC22A7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,305,538 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,749,383 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; renal medulla; ; vena cava; ; olfactory bulb; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; right testis; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	right kidney; ; human kidney; ; left lobe of liver; ; proximal tubule; ; embryo; ; embryo; ; morula; ; convoluted tubule; ; proximal convoluted tubule; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	organic anion transmembrane transporter activity; protein binding; inorganic anion exchanger activity; sodium-independent organic anion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; organic anion transport; transmembrane transport; anion transmembrane transport; inorganic anion transport; sodium-independent organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	10864
	108114
	ENSG00000137204
	ENSMUSG00000067144
	Q9Y694; Q5T051
	Q91WU2
	NM_006672; NM_153320
	NM_144856
	NP_006663; NP_696961
	NP_659105
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 01:51, 13 August 2023

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.^[5]^[6]^[7]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137204 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067144 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID 9650585. S2CID 30015233.
^ Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID 10773670. S2CID 8702529.
^ ^a ^b "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP". Mol. Pharmacol. 73 (4): 1151–8. doi:10.1124/mol.107.043117. PMC 2698938. PMID 18216183.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID 12023506.
Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID 11907186. S2CID 7739298.
Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.
Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-8] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137204 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067144 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9650585-5] Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID 9650585. S2CID 30015233.

[pmid10773670-6] Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID 10773670. S2CID 8702529.

[entrez-7] "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

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[2]

[3]

[4]

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[§ 1]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=10864}}
+{{Infobox_gene}}
-'''Solute carrier family 22 member 7''' is a [[protein]] that in humans is encoded by the ''SLC22A7'' [[gene]].<ref name="pmid9650585">{{cite journal | author = Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H | title = Identification of multispecific organic anion transporter 2 expressed predominantly in the liver | journal = FEBS Lett | volume = 429 | issue = 2 | pages = 179–82 | date = Jul 1998 | pmid = 9650585 | pmc =  | doi =10.1016/S0014-5793(98)00585-7  }}</ref><ref name="pmid10773670">{{cite journal | author = Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM | title = Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids | journal = Cytogenet Cell Genet | volume = 88 | issue = 1–2 | pages = 76–7 | date = Jun 2000 | pmid = 10773670 | pmc =  | doi =10.1159/000015489  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864| accessdate = }}</ref>
+'''Solute carrier family 22 member 7''' is a [[protein]] that in humans is encoded by the [[gene]] ''SLC22A7''.<ref name="pmid9650585">{{cite journal | vauthors = Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H | title = Identification of multispecific organic anion transporter 2 expressed predominantly in the liver | journal = FEBS Lett | volume = 429 | issue = 2 | pages = 179–82 | date = Jul 1998 | pmid = 9650585 | doi =10.1016/S0014-5793(98)00585-7  | s2cid = 30015233 | doi-access = free }}</ref><ref name="pmid10773670">{{cite journal | vauthors = Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM | title = Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids | journal = Cytogenet Cell Genet | volume = 88 | issue = 1–2 | pages = 76–7 | date = Jun 2000 | pmid = 10773670 | doi =10.1159/000015489  | s2cid = 8702529 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864}}</ref>
+The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic [[anions]], some of which are potentially [[toxic]]. The encoded protein is an [[integral membrane protein]] and appears to be localized to the [[basolateral membrane]] of the [[kidney]]. Alternatively spliced [[transcript variants]] encoding different [[isoforms]] have been described.<ref name="entrez"/>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez"/>
-}}
 == Interactive pathway map ==
@@ Line 19: / Line 16: @@
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
 *{{cite journal   |vauthors=Cropp CD, Komori T, Shima JE, etal |title=Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP |journal=Mol. Pharmacol. |volume=73 |issue= 4 |pages= 1151–8 |year= 2008 |pmid= 18216183 |doi= 10.1124/mol.107.043117  | pmc=2698938 }}
 *{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
 *{{cite journal   |vauthors=Enomoto A, Takeda M, Shimoda M, etal |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797–802 |year= 2002 |pmid= 12023506 |doi=10.1124/jpet.301.3.797  }}
-*{{cite journal   |vauthors=Kimura H, Takeda M, Narikawa S, etal |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293–8 |year= 2002 |pmid= 11907186 |doi=10.1124/jpet.301.1.293  }}
+*{{cite journal   |vauthors=Kimura H, Takeda M, Narikawa S, etal |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293–8 |year= 2002 |pmid= 11907186 |doi=10.1124/jpet.301.1.293  |s2cid=7739298 }}
-*{{cite journal   |vauthors=Babu E, Takeda M, Narikawa S, etal |title=Human organic anion transporters mediate the transport of tetracycline |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=10.1254/jjp.88.69  }}
+*{{cite journal   |vauthors=Babu E, Takeda M, Narikawa S, etal |title=Human organic anion transporters mediate the transport of tetracycline |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=10.1254/jjp.88.69  |doi-access=free }}
-*{{cite journal  | author=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417–22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
+*{{cite journal  | vauthors=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417–22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
-}}
 {{refend}}
 {{NLM content}}
 {{Membrane transport proteins}}
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 [[Category:Solute carrier family]]
 {{membrane-protein-stub}}

Latest revision as of 01:51, 13 August 2023

Interactive pathway map

See also

References

Further reading