Sodium–hydrogen antiporter 2: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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⚫ | '''Sodium–hydrogen exchanger 2''' is a [[protein]] that in humans is encoded by the ''SLC9A2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6549}}</ref> |
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{{GNF_Protein_box |
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| image = |
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| image_source = |
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| PDB = |
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| Name = Solute carrier family 9 (sodium/hydrogen exchanger), member 2 |
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| HGNCid = 11072 |
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| Symbol = SLC9A2 |
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| AltSymbols =; NHE2 |
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| OMIM = 600530 |
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| ECnumber = |
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| Homologene = 20661 |
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| MGIid = 105075 |
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| Function = {{GNF_GO|id=GO:0015297 |text = antiporter activity}} {{GNF_GO|id=GO:0015299 |text = solute:hydrogen antiporter activity}} {{GNF_GO|id=GO:0015385 |text = sodium:hydrogen antiporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} |
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| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} |
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| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006885 |text = regulation of pH}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 6549 |
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| Hs_Ensembl = ENSG00000115616 |
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| Hs_RefseqProtein = NP_003039 |
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| Hs_RefseqmRNA = NM_003048 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = 2 |
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| Hs_GenLoc_start = 102602598 |
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| Hs_GenLoc_end = 102694239 |
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| Hs_Uniprot = Q9UBY0 |
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| Mm_EntrezGene = 226999 |
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| Mm_Ensembl = ENSMUSG00000026062 |
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| Mm_RefseqmRNA = NM_001033289 |
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| Mm_RefseqProtein = NP_001028461 |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = 1 |
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| Mm_GenLoc_start = 40626171 |
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| Mm_GenLoc_end = 40713812 |
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| Mm_Uniprot = |
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}} |
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}} |
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⚫ | ''' |
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{{PBB_Summary |
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==See also== |
==See also== |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal | author=Chow CW |title=Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. |journal=Clinical and Investigative Medicine |volume=22 |issue= 5 |pages= 195–206 |year= 1999 |pmid= 10579058 }} |
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{{PBB_Further_reading |
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*{{cite journal |vauthors=Kulanthaivel P, Furesz TC, Moe AJ, etal |title=Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. |journal=Biochem. J. |volume=284 |issue= 1|pages= 33–8 |year= 1992 |pmid= 1318024 |doi= 10.1042/bj2840033| pmc=1132693 }} |
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| citations = |
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*{{cite journal |
*{{cite journal |vauthors=Collins JF, Honda T, Knobel S, etal |title=Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 9 |pages= 3938–42 |year= 1993 |pmid= 7683411 |doi=10.1073/pnas.90.9.3938 | pmc=46421 |bibcode=1993PNAS...90.3938C |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Ghishan FK, Knobel SM, Summar M |title=Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2). |journal=Genomics |volume=30 |issue= 1 |pages= 25–30 |year= 1996 |pmid= 8595899 |doi= 10.1006/geno.1995.0004 }} |
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*{{cite journal |
*{{cite journal |vauthors=Dudeja PK, Rao DD, Syed I, etal |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483–93 |year= 1996 |pmid= 8843774 |doi= 10.1152/ajpgi.1996.271.3.G483}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=10.1073/pnas.93.22.12631 | pmc=38044 |bibcode=1996PNAS...9312631L |doi-access=free }} |
||
*{{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|doi-access=free |last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }} |
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*{{cite journal | author=Dudeja PK, Rao DD, Syed I, ''et al.'' |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483-93 |year= 1996 |pmid= 8843774 |doi= }} |
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*{{cite journal |
*{{cite journal |vauthors=Chow CW, Woodside M, Demaurex N, etal |title=Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10481–8 |year= 1999 |pmid= 10187839 |doi=10.1074/jbc.274.15.10481 |doi-access=free }} |
||
*{{cite journal |
*{{cite journal |vauthors=Malakooti J, Dahdal RY, Schmidt L, etal |title=Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. |journal=Am. J. Physiol. |volume=277 |issue= 2 Pt 1 |pages= G383–90 |year= 1999 |pmid= 10444453 |doi= 10.1152/ajpgi.1999.277.2.G383|s2cid=4467617 }} |
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*{{cite journal |
*{{cite journal |vauthors=Malakooti J, Dahdal RY, Dudeja PK, etal |title=The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=280 |issue= 4 |pages= G763–73 |year= 2001 |pmid= 11254504 |doi= 10.1152/ajpgi.2001.280.4.G763|s2cid=10642872 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Pang T, Su X, Wakabayashi S, Shigekawa M |title=Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17367–72 |year= 2001 |pmid= 11350981 |doi= 10.1074/jbc.M100296200 |doi-access= free }} |
||
*{{cite journal | |
*{{cite journal |vauthors=Repishti M, Hogan DL, Pratha V, etal |title=Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G159–63 |year= 2001 |pmid= 11408268 |doi= 10.1152/ajpgi.2001.281.1.G159|s2cid=616434 }} |
||
*{{cite journal |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Lacey HA, Nolan T, Greenwood SL, etal |title=Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR. |journal=Placenta |volume=26 |issue= 1 |pages= 93–8 |year= 2005 |pmid= 15664417 |doi= 10.1016/j.placenta.2004.05.005 }} |
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*{{cite journal |
*{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }} |
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*{{cite journal |
*{{cite journal |vauthors=Pearse I, Zhu YX, Murray EJ, etal |title=Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. |journal=Biochem. J. |volume=407 |issue= 1 |pages= 101–11 |year= 2007 |pmid= 17561809 |doi= 10.1042/BJ20070364 | pmc=2267401 }} |
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*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }} |
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*{{cite journal | author=Pearse I, Zhu YX, Murray EJ, ''et al.'' |title=Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. |journal=Biochem. J. |volume=407 |issue= 1 |pages= 101-11 |year= 2007 |pmid= 17561809 |doi= 10.1042/BJ20070364 }} |
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}} |
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{{refend}} |
{{refend}} |
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⚫ | |||
{{Membrane transport proteins}} |
{{Membrane transport proteins}} |
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[[Category:Transport proteins]] |
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{{DEFAULTSORT:Sodium-hydrogen antiporter 2}} |
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[[Category:Transmembrane proteins]] |
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[[Category:Solute carrier family]] |
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⚫ |
Latest revision as of 07:44, 29 December 2023
SLC9A2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SLC9A2, NHE2, solute carrier family 9 member A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600530; MGI: 105075; HomoloGene: 20661; GeneCards: SLC9A2; OMA:SLC9A2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.[5]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000115616 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026062 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".
Further reading
[edit]- Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and Investigative Medicine. 22 (5): 195–206. PMID 10579058.
- Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". Biochem. J. 284 (1): 33–8. doi:10.1042/bj2840033. PMC 1132693. PMID 1318024.
- Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. Bibcode:1993PNAS...90.3938C. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
- Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
- Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. doi:10.1152/ajpgi.1996.271.3.G483. PMID 8843774.
- Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
- Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". Am. J. Physiol. 277 (2 Pt 1): G383–90. doi:10.1152/ajpgi.1999.277.2.G383. PMID 10444453. S2CID 4467617.
- Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. doi:10.1152/ajpgi.2001.280.4.G763. PMID 11254504. S2CID 10642872.
- Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
- Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. doi:10.1152/ajpgi.2001.281.1.G159. PMID 11408268. S2CID 616434.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.