Proton-coupled amino acid transporter 1: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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'''Proton-coupled amino acid transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC36A1'' [[gene]].<ref name="pmid11959859">{{cite journal | |
'''Proton-coupled amino acid transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC36A1'' [[gene]].<ref name="pmid11959859">{{cite journal | vauthors = Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H | title = Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters | journal = J Biol Chem | volume = 277 | issue = 25 | pages = 22966–73 |date=Jun 2002 | pmid = 11959859 | doi = 10.1074/jbc.M200374200 | doi-access = free }}</ref><ref name="pmid11390972">{{cite journal | vauthors = Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B | title = Identification and characterization of a lysosomal transporter for small neutral amino acids | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 13 | pages = 7206–11 |date=Jun 2001 | pmid = 11390972 | pmc = 34647 | doi = 10.1073/pnas.121183498 | bibcode = 2001PNAS...98.7206S | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358}}</ref> |
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==See also== |
==See also== |
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* [[Solute carrier family]] |
* [[Solute carrier family]] |
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* [[Proton coupled amino acid transporter]] |
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==References== |
==References== |
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==Further reading== |
==Further reading== |
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*{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }} |
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*{{cite journal |
*{{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }} |
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*{{cite journal |
*{{cite journal |vauthors=Chen Z, Fei YJ, Anderson CM, etal |title=Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 |journal=J. Physiol. |volume=546 |issue= Pt 2 |pages= 349–61 |year= 2003 |pmid= 12527723 |doi=10.1113/jphysiol.2002.026500 | pmc=2342508 }} |
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*{{cite journal |
*{{cite journal |vauthors=Wreden CC, Johnson J, Tran C, etal |title=The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1265–75 |year= 2003 |pmid= 12598615 |doi= 10.1523/JNEUROSCI.23-04-01265.2003|pmc= 6742289 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Boll M, Foltz M, Rubio-Aliaga I, Daniel H |title=A cluster of proton/amino acid transporter genes in the human and mouse genomes |journal=Genomics |volume=82 |issue= 1 |pages= 47–56 |year= 2004 |pmid= 12809675 |doi=10.1016/S0888-7543(03)00099-5 }} |
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*{{cite journal |
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Bermingham JR, Pennington J |title=Organization and expression of the SLC36 cluster of amino acid transporter genes |journal=Mamm. Genome |volume=15 |issue= 2 |pages= 114–25 |year= 2004 |pmid= 15058382 |doi=10.1007/s00335-003-2319-3 |s2cid=21418124 }} |
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*{{cite journal |
*{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }} |
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*{{cite journal |
*{{cite journal |vauthors=Anderson CM, Grenade DS, Boll M, etal |title=H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat |journal=Gastroenterology |volume=127 |issue= 5 |pages= 1410–22 |year= 2004 |pmid= 15521011 |doi=10.1053/j.gastro.2004.08.017 |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Anderson CM, Thwaites DT |title=Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1) |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 604–13 |year= 2005 |pmid= 15754324 |doi= 10.1002/jcp.20337 |s2cid=31443973 }} |
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*{{cite journal |
*{{cite journal |vauthors=Abbot EL, Grenade DS, Kennedy DJ, etal |title=Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1 |journal=Br. J. Pharmacol. |volume=147 |issue= 3 |pages= 298–306 |year= 2006 |pmid= 16331283 |doi= 10.1038/sj.bjp.0706557 | pmc=1751303 }} |
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*{{cite journal |
*{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }} |
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*{{cite journal |
*{{cite journal |vauthors=Kuan YH, Gruebl T, Soba P, etal |title=PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40114–23 |year= 2007 |pmid= 17050537 |doi= 10.1074/jbc.M605407200 |doi-access= free }} |
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*{{cite journal | author=Kuan YH, Gruebl T, Soba P, ''et al.'' |title=PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40114–23 |year= 2007 |pmid= 17050537 |doi= 10.1074/jbc.M605407200 }} |
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{{refend}} |
{{refend}} |
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{{NLM content}} |
{{NLM content}} |
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{{Membrane transport proteins}} |
{{Membrane transport proteins}} |
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[[Category:Solute carrier family]] |
[[Category:Solute carrier family]] |
Latest revision as of 03:17, 1 January 2024
Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.[5][6][7]
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.[7]
See also[edit]
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000123643 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020261 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem. 277 (25): 22966–73. doi:10.1074/jbc.M200374200. PMID 11959859.
- ^ Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13): 7206–11. Bibcode:2001PNAS...98.7206S. doi:10.1073/pnas.121183498. PMC 34647. PMID 11390972.
- ^ a b "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1".
Further reading[edit]
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Chen Z, Fei YJ, Anderson CM, et al. (2003). "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2". J. Physiol. 546 (Pt 2): 349–61. doi:10.1113/jphysiol.2002.026500. PMC 2342508. PMID 12527723.
- Wreden CC, Johnson J, Tran C, et al. (2003). "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons". J. Neurosci. 23 (4): 1265–75. doi:10.1523/JNEUROSCI.23-04-01265.2003. PMC 6742289. PMID 12598615.
- Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes". Genomics. 82 (1): 47–56. doi:10.1016/S0888-7543(03)00099-5. PMID 12809675.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes". Mamm. Genome. 15 (2): 114–25. doi:10.1007/s00335-003-2319-3. PMID 15058382. S2CID 21418124.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Anderson CM, Grenade DS, Boll M, et al. (2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat". Gastroenterology. 127 (5): 1410–22. doi:10.1053/j.gastro.2004.08.017. PMID 15521011.
- Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)". J. Cell. Physiol. 204 (2): 604–13. doi:10.1002/jcp.20337. PMID 15754324. S2CID 31443973.
- Abbot EL, Grenade DS, Kennedy DJ, et al. (2006). "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1". Br. J. Pharmacol. 147 (3): 298–306. doi:10.1038/sj.bjp.0706557. PMC 1751303. PMID 16331283.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Kuan YH, Gruebl T, Soba P, et al. (2007). "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2". J. Biol. Chem. 281 (52): 40114–23. doi:10.1074/jbc.M605407200. PMID 17050537.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.