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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Solute carrier family 22 member 18''' is a [[protein]] that in humans is encoded by the ''SLC22A18'' [[gene]].<ref name="pmid9499412">{{cite journal | vauthors = Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B | title = IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes | journal = Human Molecular Genetics | volume = 7 | issue = 4 | pages = 597–608 | date = April 1998 | pmid = 9499412 | pmc = | doi = 10.1093/hmg/7.4.597 }}</ref><ref name="pmid9520460">{{cite journal | vauthors = Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M | title = Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3873–8 | date = March 1998 | pmid = 9520460 | pmc = 19930 | doi = 10.1073/pnas.95.7.3873 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = }}</ref>
'''Solute carrier family 22 member 18''' is a [[protein]] that in humans is encoded by the ''SLC22A18'' [[gene]].<ref name="pmid9499412">{{cite journal | vauthors = Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B | title = IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes | journal = Human Molecular Genetics | volume = 7 | issue = 4 | pages = 597–608 | date = April 1998 | pmid = 9499412 | doi = 10.1093/hmg/7.4.597 | doi-access = free }}</ref><ref name="pmid9520460">{{cite journal | vauthors = Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M | title = Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3873–8 | date = March 1998 | pmid = 9520460 | pmc = 19930 | doi = 10.1073/pnas.95.7.3873 | bibcode = 1998PNAS...95.3873S | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002}}</ref>


== Function ==
== Function ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Akiyama S | title = [Mechanisms of drug resistance and reversal of the resistance] | journal = Human Cell | volume = 14 | issue = 4 | pages = 257–60 | date = December 2001 | pmid = 11925925 | doi = }}
* {{cite journal | vauthors = Akiyama S | title = [Mechanisms of drug resistance and reversal of the resistance] | journal = Human Cell | volume = 14 | issue = 4 | pages = 257–60 | date = December 2001 | pmid = 11925925 }}
* {{cite journal | vauthors = Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ | title = Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain | journal = Genomics | volume = 49 | issue = 1 | pages = 38–51 | date = April 1998 | pmid = 9570947 | doi = 10.1006/geno.1998.5221 }}
* {{cite journal | vauthors = Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ | title = Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain | journal = Genomics | volume = 49 | issue = 1 | pages = 38–51 | date = April 1998 | pmid = 9570947 | doi = 10.1006/geno.1998.5221 }}
* {{cite journal | vauthors = Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J | title = Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules | journal = FEBS Letters | volume = 433 | issue = 3 | pages = 245–50 | date = August 1998 | pmid = 9744804 | doi = 10.1016/S0014-5793(98)00907-7 }}
* {{cite journal | vauthors = Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J | title = Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules | journal = FEBS Letters | volume = 433 | issue = 3 | pages = 245–50 | date = August 1998 | pmid = 9744804 | doi = 10.1016/S0014-5793(98)00907-7 | s2cid = 6967408 | doi-access = free }}
* {{cite journal | vauthors = Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP | title = Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5 | journal = Cancer Research | volume = 58 | issue = 18 | pages = 4155–9 | date = September 1998 | pmid = 9751628 | doi = }}
* {{cite journal | vauthors = Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP | title = Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5 | journal = Cancer Research | volume = 58 | issue = 18 | pages = 4155–9 | date = September 1998 | pmid = 9751628 }}
* {{cite journal | vauthors = Morisaki H, Hatada I, Morisaki T, Mukai T | title = A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice | journal = DNA Research | volume = 5 | issue = 4 | pages = 235–40 | date = August 1998 | pmid = 9802569 | doi = 10.1093/dnares/5.4.235 }}
* {{cite journal | vauthors = Morisaki H, Hatada I, Morisaki T, Mukai T | title = A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice | journal = DNA Research | volume = 5 | issue = 4 | pages = 235–40 | date = August 1998 | pmid = 9802569 | doi = 10.1093/dnares/5.4.235 | citeseerx = 10.1.1.505.8561 }}
* {{cite journal | vauthors = Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP | title = Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain | journal = Genome Research | volume = 10 | issue = 11 | pages = 1697–710 | date = November 2000 | pmid = 11076855 | doi = 10.1101/gr.161800 }}
* {{cite journal | vauthors = Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP | title = Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain | journal = Genome Research | volume = 10 | issue = 11 | pages = 1697–710 | date = November 2000 | pmid = 11076855 | doi = 10.1101/gr.161800 | doi-access = free }}
* {{cite journal | vauthors = Yamada HY, Gorbsky GJ | title = Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 | journal = Oncogene | volume = 25 | issue = 9 | pages = 1330–9 | date = March 2006 | pmid = 16314844 | pmc = 2713668 | doi = 10.1038/sj.onc.1209167 }}
* {{cite journal | vauthors = Yamada HY, Gorbsky GJ | title = Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 | journal = Oncogene | volume = 25 | issue = 9 | pages = 1330–9 | date = March 2006 | pmid = 16314844 | pmc = 2713668 | doi = 10.1038/sj.onc.1209167 }}
* {{cite journal | vauthors = Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A | title = Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer | journal = Genomics | volume = 88 | issue = 1 | pages = 12–7 | date = July 2006 | pmid = 16624517 | doi = 10.1016/j.ygeno.2006.02.004 }}
* {{cite journal | vauthors = Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A | title = Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer | journal = Genomics | volume = 88 | issue = 1 | pages = 12–7 | date = July 2006 | pmid = 16624517 | doi = 10.1016/j.ygeno.2006.02.004 | doi-access = }}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}



[[Category:Solute carrier family]]
[[Category:Solute carrier family]]

Revision as of 06:20, 1 January 2024

SLC22A18
Identifiers
AliasesSLC22A18, BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A, solute carrier family 22 member 18
External IDsOMIM: 602631; MGI: 1336884; HomoloGene: 1918; GeneCards: SLC22A18; OMA:SLC22A18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5002

18400

Ensembl

ENSG00000276130
ENSG00000110628

ENSMUSG00000000154

UniProt

Q96BI1

Q78KK3

RefSeq (mRNA)

NM_002555
NM_183233
NM_001315501
NM_001315502

NM_001042760
NM_008767

RefSeq (protein)

NP_001302430
NP_001302431
NP_002546
NP_899056

NP_001036225
NP_032793

Location (UCSC)Chr 11: 2.9 – 2.93 MbChr 7: 143.03 – 143.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[5][6][7]

Function

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[7]

See also

References

  1. ^ a b c ENSG00000110628 GRCh38: Ensembl release 89: ENSG00000276130, ENSG00000110628 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000154 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (April 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Human Molecular Genetics. 7 (4): 597–608. doi:10.1093/hmg/7.4.597. PMID 9499412.
  6. ^ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (March 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3873–8. Bibcode:1998PNAS...95.3873S. doi:10.1073/pnas.95.7.3873. PMC 19930. PMID 9520460.
  7. ^ a b "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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