Mazindol
-Mazindol_Enantiomere_Structural_Formulae.png) | |
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 93% |
| Metabolism | Hepatic |
| Elimination half-life | 10-13 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.040.764 |
| Chemical and physical data | |
| Formula | C16H13ClN2O |
| Molar mass | 284.74 g/mol g·mol−1 |
Mazindol is a central nervous system stimulant. It is a tricyclic compound (not to be confused with tricyclic antidepressants). It is marketed under the brand names Mazanor and Sanorex.
Indications
Mazindol is used in short-term (i.e., a few weeks) treatment of exogenous obesity, in combination with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m2), or in patients with a body mass index of 27 kg/m2 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia.
Pharmacology
Mazindol is a sympathomimetic amine, which is similar to amphetamine. It stimulates the central nervous system, which increases heart rate and blood pressure, and decreases appetite. Sympathomimetic anoretics (appetite suppressants) are used in the short-term treatment of obesity. Their appetite-reducing effect tends to decrease after a few weeks of treatment. Because of this, these medicines are useful only during the first few weeks of a weight-loss program.
Mechanism of action
Although the mechanism of action of the sympathomimetics in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Like other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to act as a reuptake inhibitor of norepinephrine.
Mazindol is a reuptake inhibitor of noradrenaline, dopamine, and also serotonin.
Analogs of mazindol are obviously also known to have been made.[1]
Overdose
Symptoms of a mazindol overdose include: restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.
Production
(Satendra Singh, 2000) pages 87-90
Ana
| Compd[2] | hSERT | hNET | hDAT |
|---|---|---|---|
| Mazindol | 94 | 4.9 | 43 |
| 1 | 15 | 6.9 | 6.0 |
| 2 | 2140 | 2.8 | 730 |
| 3 | 1.8 | 4.5 | 66 |
| 4 | 53 | 4.9 | 3.7 |
| 5 | 60 | 1.9 | 59.0 |
| 6 | 94 | 4.1 | 30.4 |
| 7 | 83 | 0.62 | 2.21 |
References
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