Sodium-dependent multivitamin transporter

SLC5A6
Identifiers
Aliases	SLC5A6, SMVT, solute carrier family 5 member 6, NERIB
External IDs	OMIM: 604024; MGI: 2660847; HomoloGene: 23277; GeneCards: SLC5A6; OMA:SLC5A6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,212,958 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,206,268 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; placenta; ; left uterine tube; ; corpus epididymis; ; retinal pigment epithelium; ; gastrocnemius muscle; ; subcutaneous adipose tissue; ; minor salivary glands; ; gastric mucosa; ; canal of the cervix;
	Top expressed in
	morula; ; yolk sac; ; blastocyst; ; proximal tubule; ; lip; ; urethra; ; superior frontal gyrus; ; ankle joint; ; pericardium; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; sodium-dependent multivitamin transmembrane transporter activity; transmembrane transporter activity;
Cellular component	vesicle membrane; integral component of membrane; brush border membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; sodium ion transport; biotin transport; pantothenate transmembrane transport; transmembrane transport; biotin metabolic process; pantothenate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8884
	330064
	ENSG00000138074
	ENSMUSG00000006641
	Q9Y289
	Q5U4D8
	NM_021095
	NM_001177621; NM_001177622; NM_177870; NM_001360022
	NP_066918
	NP_001171092; NP_001171093; NP_808538; NP_001346951
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.^[5]^[6]^[7]

It is a putative transporter for uptake of biotin and pantothenic acid at the blood-brain barrier.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138074 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006641 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
^ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
^ Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

Prasad PD, Wang H, Huang W, et al. (1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Arch. Biochem. Biophys. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
Zempleni J, Steven Stanley J, Mock DM (2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
Dey S, Subramanian VS, Chatterjee NS, et al. (2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochim. Biophys. Acta. 1574 (2): 187–92. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Balamurugan K, Ortiz A, Said HM (2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (1): G73–7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Balamurugan K, Vaziri ND, Said HM (2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". Am. J. Physiol. Renal Physiol. 288 (4): F823–31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Luo S, Kansara VS, Zhu X, et al. (2006). "Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery". Mol. Pharm. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865.
Reidling JC, Nabokina SM, Said HM (2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G275–81. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
Reidling JC, Said HM (2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". Am. J. Physiol., Cell Physiol. 292 (4): C1305–12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138074 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006641 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9516450-5] Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.

[pmid10329687-6] Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.

[entrez-7] "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".

[Uchida_2015-8] Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

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References

Further reading