Anion exchange transporter

SLC26A7
Identifiers
Aliases	SLC26A7, SUT2, solute carrier family 26 member 7
External IDs	OMIM: 608479; MGI: 2384791; HomoloGene: 13770; GeneCards: SLC26A7; OMA:SLC26A7 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	91,398,155 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	14,621,805 bp
RNA expression pattern
	Top expressed in
	thyroid gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; retinal pigment epithelium; ; renal medulla; ; human kidney; ; testicle; ; endometrium; ; lymph node; ; placenta;
	Top expressed in
	vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; ciliary body; ; iris; ; olfactory epithelium; ; renal corpuscle; ; vestibular sensory epithelium; ; pineal gland; ; lumbar spinal ganglion; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	anion channel activity; anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; oxalate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; recycling endosome membrane; basolateral plasma membrane;
Biological process	oxalate transport; sulfate transport; gastric acid secretion; regulation of membrane potential; regulation of intracellular pH; ion transport; anion transport; bicarbonate transport; chloride transport; chloride transmembrane transport; anion transmembrane transport; sulfate transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	115111
	208890
	ENSG00000147606
	ENSMUSG00000040569
	Q8TE54
	Q8R2Z3
	NM_134266; NM_001282356; NM_001282357; NM_052832
	NM_145947
	NP_001269285; NP_001269286; NP_439897; NP_599028
	NP_666059
	Wikidata
View/Edit Human	View/Edit Mouse

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.^[5]^[6]^[7]^[8]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147606 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040569 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (April 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". The Journal of Biological Chemistry. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (February 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
^ Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M (April 2006). "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". Journal of the American Society of Nephrology. 17 (4): 956–67. doi:10.1681/ASN.2005111174. PMID 16524946.
^ ^a ^b "Entrez Gene: SLC26A7 solute carrier family 26, member 7".

Markovich D (October 2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiological Reviews. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495.
Petrovic S, Ju X, Barone S, Seidler U, Alper SL, Lohi H, Kere J, Soleimani M (June 2003). "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells". American Journal of Physiology. Gastrointestinal and Liver Physiology. 284 (6): G1093–103. doi:10.1152/ajpgi.00454.2002. PMID 12736153.
Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M (January 2004). "SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct". American Journal of Physiology. Renal Physiology. 286 (1): F161–9. doi:10.1152/ajprenal.00219.2003. PMID 12965893.
Barone S, Amlal H, Xu J, Kujala M, Kere J, Petrovic S, Soleimani M (August 2004). "Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct". Journal of the American Society of Nephrology. 15 (8): 2002–11. doi:10.1097/01.ASN.0000135060.83250.07. PMID 15284286.
Kujala M, Tienari J, Lohi H, Elomaa O, Sariola H, Lehtonen E, Kere J (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Experimental Nephrology. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147606 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040569 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11834742-5] Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (April 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". The Journal of Biological Chemistry. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.

[pmid11829495-6] Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (February 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.

[pmid16524946-7] Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M (April 2006). "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". Journal of the American Society of Nephrology. 17 (4): 956–67. doi:10.1681/ASN.2005111174. PMID 16524946.

[entrez-8] "Entrez Gene: SLC26A7 solute carrier family 26, member 7".

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Anion exchange transporter

Function

See also

References

Further reading