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AliasesUCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDsOMIM: 601693 MGI: 109354 HomoloGene: 2516 GeneCards: UCP2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for UCP2
Genomic location for UCP2
Band11q13.4Start73,974,672 bp[1]
End73,983,246 bp[1]
RNA expression pattern
PBB GE UCP2 208998 at fs.png

PBB GE UCP2 208997 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 73.97 – 73.98 MbChr 7: 100.49 – 100.5 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.[5]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. Although it was originally thought to play a role in nonshivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.[6] Chromosomal order is 5'-UCP3-UCP2-3'.[7]

Mitochondrial Uncoupling Protein 2

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175567 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033685 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
  6. ^ Arsenijevic D, Onuma H, Pecqueur C, et al. (December 2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nat. Genet. 26 (4): 435–9. doi:10.1038/82565. PMID 11101840.
  7. ^ "Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)".

Further reading[edit]