Y+L amino acid transporter 2

SLC7A6
Identifiers
Aliases	SLC7A6, LAT-2, LAT3, y+LAT-2, solute carrier family 7 member 6
External IDs	OMIM: 605641; MGI: 2142598; HomoloGene: 62496; GeneCards: SLC7A6; OMA:SLC7A6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,301,823 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,925,338 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; gastric mucosa; ; subcutaneous adipose tissue; ; tibialis anterior muscle; ; left ventricle; ; tibial nerve; ; abdominal fat; ; left lobe of thyroid gland; ; right auricle;
	Top expressed in
	spermatocyte; ; primitive streak; ; embryo; ; neural tube; ; external carotid artery; ; abdominal wall; ; epiblast; ; ventricular zone; ; internal carotid artery; ; otic vesicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-amino acid transmembrane transporter activity; antiporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane; intracellular membrane-bounded organelle;
Biological process	cellular amino acid metabolic process; amino acid transmembrane transport; amino acid transport; leukocyte migration; L-alpha-amino acid transmembrane transport; transmembrane transport; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9057
	330836
	ENSG00000103064
	ENSMUSG00000031904
	Q92536
	Q8BGK6
	NM_001076785; NM_003983
	NM_178798; NM_001357381; NM_001357382
	NP_001070253; NP_003974; NP_001070253.1; NP_003974.3
	NP_848913; NP_001344310; NP_001344311
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 7 member 6 also known as cationic amino acid transporter, y+ system or Y+L amino acid transporter 2 is a protein that in humans is encoded by the SLC7A6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
^ Pfeiffer R; Rossier G; Spindler B; Meier C; Kühn L; Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". EMBO J. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

Sekine Y; Nishibori Y; Akimoto Y; Kudo A; Ito N; Fukuhara D; Kurayama R; Higashihara E; Babu E; Kanai Y; Asanuma K; Nagata M; Majumdar A; Tryggvason K; Yan K (July 2009). "Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function". J. Am. Soc. Nephrol. 20 (7): 1586–96. doi:10.1681/ASN.2008070809. PMC 2709689. PMID 19443642.
Suzuki Y; Yamashita R; Shirota M; Sakakibara Y; Chiba J; Mizushima-Sugano J; Nakai K; Sugano S (September 2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Torrents D; Estévez R; Pineda M; Fernández E; Lloberas J; Shi YB; Zorzano A; Palacín M (December 1998). "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance". J. Biol. Chem. 273 (49): 32437–45. doi:10.1074/jbc.273.49.32437. PMID 9829974.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bröer A; Wagner CA; Lang F; Bröer S (August 2000). "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine". Biochem. J. 349 Pt 3 (Pt 3): 787–95. PMC 1221206. PMID 10903140.
Xu D; Hemler ME (August 2005). "Metabolic activation-related CD147-CD98 complex". Mol. Cell Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

[pmid9878049-6] Pfeiffer R; Rossier G; Spindler B; Meier C; Kühn L; Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". EMBO J. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

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Y+L amino acid transporter 2

See also

References

Further reading