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Synaptotagmins

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Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B.

There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.

Members

  • Synaptotagmin 1 (SYT1)
  • Synaptotagmin 2 (SYT2)
  • Synaptotagmin 3 (SYT3)
  • Synaptotagmin 4 (SYT4)
  • Synaptotagmin 5 (SYT5)
  • Synaptotagmin 6 (SYT6)
  • Synaptotagmin 7 (SYT7)
  • Synaptotagmin 8 (SYT8)
  • Synaptotagmin 9 (SYT9)
  • Synaptotagmin 10 (SYT10)
  • Synaptotagmin 11 (SYT11)
  • Synaptotagmin 12 (SYT12)
  • Synaptotagmin 13 (SYT13)
  • Synaptotagmin 14 (SYT14)
  • Synaptotagmin 15 (SYT15)
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