Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3gene.[5][6][7]
SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment prostate cancer cell lines with androgens upregulates the expression of SLC45A3.[7]
Regulation
There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.[8]
Friedman RS; Spies AG; Kalos M (2004). "Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate". Eur. J. Immunol. 34 (4): 1091–101. doi:10.1002/eji.200324768. PMID15048720.
Satake W, Nakabayashi Y, Mizuta I, et al. (2009). "Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease". Nat. Genet. 41 (12): 1303–7. doi:10.1038/ng.485. PMID19915576.
Kalos M, Askaa J, Hylander BL, et al. (2004). "Prostein expression is highly restricted to normal and malignant prostate tissues". Prostate. 60 (3): 246–56. doi:10.1002/pros.20043. PMID15176054.
Sheridan T; Herawi M; Epstein JI; Illei PB (2007). "The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate". Am. J. Surg. Pathol. 31 (9): 1351–5. doi:10.1097/PAS.0b013e3180536678. PMID17721190.