SLC45A3

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SLC45A3
Identifiers
AliasesSLC45A3, IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST, solute carrier family 45 member 3
External IDsMGI: 1922082 HomoloGene: 23813 GeneCards: SLC45A3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC45A3
Genomic location for SLC45A3
Band1q32.1Start205,657,851 bp[1]
End205,680,459 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033102

NM_001177628
NM_145977

RefSeq (protein)

NP_149093

NP_001171099
NP_666089

Location (UCSC)Chr 1: 205.66 – 205.68 MbChr 1: 131.96 – 131.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene.[5][6][7]

SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment prostate cancer cell lines with androgens upregulates the expression of SLC45A3.[7]

Regulation[edit]

There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158715 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026435 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: solute carrier family 45".
  6. ^ Walker MG; Volkmuth W; Sprinzak E; Hodgson D; Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
  7. ^ a b Xu J; Kalos M; Stolk JA; Zasloff EJ; Zhang X; Houghton RL; Filho AM; Nolasco M; Badaró R; Reed SG (February 2001). "Identification and characterization of prostein, a novel prostate-specific protein". Cancer Res. 61 (4): 1563–8. PMID 11245466.
  8. ^ Musiyenko A; Bitko V; Barik S (2008). "Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells". J Mol Med. 86 (3): 313–22. doi:10.1007/s00109-007-0296-9. PMC 3263384. PMID 18193184.

Further reading[edit]