Interleukin 9

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IL9
Identifiers
Aliases IL9, HP40, IL-9, P40, interleukin 9
External IDs OMIM: 146931 MGI: 96563 HomoloGene: 492 GeneCards: IL9
RNA expression pattern
PBB GE IL9 208193 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000590

NM_008373

RefSeq (protein)

NP_000581

NP_032399

Location (UCSC) Chr 5: 135.89 – 135.9 Mb Chr 13: 56.48 – 56.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.[3]

Function[edit]

Il-9 is a cytokine secreted by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells.[4] This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.[3]

Interleukin-9 has also shown to inhibit melanoma growth in mice.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: IL9 interleukin 9". 
  4. ^ Perumal, Narayanan B; Kaplan, Mark H. (2011). "Regulating IL-9 transcription in T helper cells". Cell Press. 32 (4): 146–150. PMC 3070825Freely accessible – via Science Direct. 
  5. ^ Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS (July 2012). "Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells". Nat. Med. 18 (8): 1248–53. PMC 3518666Freely accessible. PMID 22772464. doi:10.1038/nm.2856. Lay summarymedicalxpress.com. 

Further reading[edit]