CACNA2D2

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CACNA2D2
Identifiers
Aliases CACNA2D2, CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2
External IDs MGI: 1929813 HomoloGene: 4400 GeneCards: CACNA2D2
RNA expression pattern
PBB GE CACNA2D2 204811 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005505
NM_001174051
NM_001291101
NM_006030

NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263

RefSeq (protein)

NP_001005505
NP_001167522
NP_001278030
NP_006021

Location (UCSC) Chr 3: 50.36 – 50.5 Mb Chr 9: 107.4 – 107.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[3]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[3]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.