SLC10A1

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SLC10A1
Identifiers
Aliases SLC10A1, NTCP, solute carrier family 10 member 1
External IDs MGI: 97379 HomoloGene: 31126 GeneCards: SLC10A1
Targeted by Drug
cyclosporine, irbesartan[1]
RNA expression pattern
PBB GE SLC10A1 207185 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003049

NM_001177561
NM_011387

RefSeq (protein)

NP_003040

NP_001171032.1

Location (UCSC) Chr 14: 69.78 – 69.8 Mb Chr 12: 80.95 – 80.97 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[4][5]

Structure[edit]

Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa.[6]

Function[edit]

Bile acid:sodium symporters participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids. One of these absorbs bile acids from the intestinal lumen, the bile duct, and the kidney with an apical localization (ileal sodium/bile acid cotransporter). The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP).[6]

As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing an hepatic influx of bile salts. Other transported molecules include steroid hormones, thyroid hormones and various xenobiotics:[6]

Hepatitis virus entry[edit]

NTCP is a cell surface receptor necessary for the entry of hepatitis B and hepatitis D virus.[7] This entry mechanism is inhibited by myrcludex B,[8] cyclosporin A, progesterone, propranolol, bosentan, ezetimibe, as well as NTCP substrates like taurocholate, tauroursodeoxycholate and bromosulfophthalein.[6]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier family 10 member 1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1". 
  5. ^ Hagenbuch B; Meier PJ (March 1994). "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter". J. Clin. Invest. 93 (3): 1326–31. doi:10.1172/JCI117091. PMC 294097Freely accessible. PMID 8132774. 
  6. ^ a b c d Watashi, Koichi; Urban, Stephan; Li, Wenhui; Wakita, Takaji (2014). "NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry". International Journal of Molecular Sciences. 15 (2): 2892–2905. doi:10.3390/ijms15022892. ISSN 1422-0067. 
  7. ^ Yan, H.; Zhong, G.; Xu, G.; He, W.; Jing, Z.; Gao, Z.; Huang, Y.; Qi, Y.; et al. (2012). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". ELife. 1: e00049. doi:10.7554/eLife.00049. PMC 3485615Freely accessible. PMID 23150796. 
  8. ^ H. Spreitzer (14 September 2015). "Neue Wirkstoffe – Myrcludex B". Österreichische Apothekerzeitung (in German) (19/2015): 12. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.