Sodium/bile acid cotransporter
| SLC10A1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SLC10A1, NTCP, solute carrier family 10 member 1, FHCA2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 182396; MGI: 97379; HomoloGene: 31126; GeneCards: SLC10A1; OMA:SLC10A1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[5][6]
Structure
Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa.[7]
Function
Bile acid:sodium symporters participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids. One of these absorbs bile acids from the intestinal lumen, the bile duct, and the kidney with an apical localization (ileal sodium/bile acid cotransporter). The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP).[7]
As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing an hepatic influx of bile salts. Other transported molecules include steroid hormones, thyroid hormones and various xenobiotics:[7]
Hepatitis virus entry
NTCP is a cell surface receptor necessary for the entry of hepatitis B and hepatitis D virus.[8] This entry mechanism is inhibited by myrcludex B,[9] cyclosporin A, progesterone, propranolol, bosentan, ezetimibe, as well as NTCP substrates like taurocholate, tauroursodeoxycholate and bromosulfophthalein.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100652 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021135 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1".
- ^ Hagenbuch B; Meier PJ (March 1994). "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter". J. Clin. Invest. 93 (3): 1326–31. doi:10.1172/JCI117091. PMC 294097. PMID 8132774.
- ^ a b c d Watashi, Koichi; Urban, Stephan; Li, Wenhui; Wakita, Takaji (2014). "NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry". International Journal of Molecular Sciences. 15 (2): 2892–2905. doi:10.3390/ijms15022892. ISSN 1422-0067.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Yan, H.; Zhong, G.; Xu, G.; He, W.; Jing, Z.; Gao, Z.; Huang, Y.; Qi, Y.; et al. (2012). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". ELife. 1: e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ H. Spreitzer (14 September 2015). "Neue Wirkstoffe – Myrcludex B". Österreichische Apothekerzeitung (in German) (19/2015): 12.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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