SLC12A8

SLC12A8
Identifiers
Aliases	SLC12A8, CCC9, solute carrier family 12 member 8
External IDs	OMIM: 611316; MGI: 2443672; HomoloGene: 11628; GeneCards: SLC12A8; OMA:SLC12A8 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	125,212,864 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,484,505 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; oocyte; ; parotid gland; ; periodontal fiber; ; gallbladder; ; decidua; ; secondary oocyte; ; body of pancreas; ; pancreatic ductal cell;
	Top expressed in
	gastrula; ; submandibular gland; ; parotid gland; ; crypt of lieberkuhn of small intestine; ; duodenum; ; large intestine; ; colon; ; pyloric antrum; ; ileum; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; potassium:chloride symporter activity;
Cellular component	integral component of membrane; membrane;
Biological process	potassium ion transport; ion transport; transmembrane transport; potassium ion transmembrane transport; cell volume homeostasis; chloride ion homeostasis; potassium ion homeostasis; chloride transmembrane transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	84561
	171286
	ENSG00000221955
	ENSMUSG00000035506
	A0AV02; H7C5L2
	Q8VI23
	NM_024628; NM_001195483
	NM_001083902; NM_134251; NM_001370999
	NP_001182412; NP_078904
	NP_001077371; NP_599012; NP_001357928
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 12 member 8 (SLC12A8), also known as cation-chloride cotransporter 9 (CCC9), is a protein that in humans is encoded by the SLC12A8 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221955 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035506 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 12 (potassium/chloride transporters)".
^ Hewett D; Samuelsson L; Polding J; Enlund F; Smart D; Cantone K; See CG; Chadha S; Inerot A; Enerback C; Montgomery D; Christodolou C; Robinson P; Matthews P; Plumpton M; Wahlstrom J; Swanbeck G; Martinsson T; Roses A; Riley J; Purvis I (March 2002). "Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map". Genomics. 79 (3): 305–314. doi:10.1006/geno.2002.6720. PMID 11863360.

Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Adams MD; Kerlavage AR; Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Daigle ND; Carpentier GA; Frenette-Cotton R; et al. (2009). "Molecular characterization of a human cation-Cl⁻ cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport". J. Cell. Physiol. 220 (3): 680–9. doi:10.1002/jcp.21814. PMID 19472210. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hebert SC; Mount DB; Gamba G (2004). "Molecular physiology of cation-coupled Cl⁻ cotransport: the SLC12 family". Pflugers Arch. 447 (5): 580–593. doi:10.1007/s00424-003-1066-3. PMID 12739168.
Hüffmeier U; Lascorz J; Traupe H; et al. (2005). "Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris". J. Invest. Dermatol. 125 (5): 906–12. doi:10.1111/j.0022-202X.2005.23847.x. PMID 16297188. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221955 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035506 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 12 (potassium/chloride transporters)".

[pmid11863360-6] Hewett D; Samuelsson L; Polding J; Enlund F; Smart D; Cantone K; See CG; Chadha S; Inerot A; Enerback C; Montgomery D; Christodolou C; Robinson P; Matthews P; Plumpton M; Wahlstrom J; Swanbeck G; Martinsson T; Roses A; Riley J; Purvis I (March 2002). "Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map". Genomics. 79 (3): 305–314. doi:10.1006/geno.2002.6720. PMID 11863360.

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References

Further reading