Monocarboxylate transporter 4

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SLC16A3
Identifiers
Aliases SLC16A3, MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4, solute carrier family 16 member 3
External IDs MGI: 1933438 HomoloGene: 37900 GeneCards: 9123
RNA expression pattern
PBB GE SLC16A3 202855 s at tn.png

PBB GE SLC16A3 202856 s at tn.png

PBB GE SLC16A3 217691 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001038653
NM_001038654
NM_030696

RefSeq (protein)

NP_001033742.1
NP_001033743.1
NP_109621.1

Location (UCSC) Chr 17: 82.23 – 82.26 Mb Chr 11: 120.95 – 120.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.[1][2]

Northern and western blotting and EST database analyses showed MCT4 to be widely expressed and especially so in glycolytic tissues such as white skeletal muscle fibers, astrocytes, white blood cells, chondrocytes, and some mammalian cell lines. Because of this, it has been proposed that the properties of MCT4 might be especially appropriate for export of lactate derived from glycolysis. MCT4 exhibits a lower affinity for most substrates and inhibitors than MCT1, with Km and Ki values some 5–10-fold higher. The high Km for pyruvate may be especially significant as this avoids loss of pyruvate from the cell which, were it to occur, would prevent removal of the reduced form of nicotinamide adenine dinucleotide (NADH) produced in glycolysis by reduction of pyruvate to lactate.

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