Monocarboxylate transporter 4

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Solute carrier family 16 (monocarboxylate transporter), member 3
Identifiers
Symbols SLC16A3 ; MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4
External IDs OMIM603877 MGI1933438 HomoloGene37900 GeneCards: SLC16A3 Gene
RNA expression pattern
PBB GE SLC16A3 202855 s at tn.png
PBB GE SLC16A3 202856 s at tn.png
PBB GE SLC16A3 217691 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9123 80879
Ensembl ENSG00000141526 ENSMUSG00000025161
UniProt O15427 P57787
RefSeq (mRNA) NM_001042422 NM_001038653
RefSeq (protein) NP_001035887 NP_001033742
Location (UCSC) Chr 17:
82.23 – 82.26 Mb
Chr 11:
120.95 – 120.96 Mb
PubMed search [1] [2]

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.[1][2]

Northern and western blotting and EST database analyses showed MCT4 to be widely expressed and especially so in glycolytic tissues such as white skeletal muscle fibers, astrocytes, white blood cells, chondrocytes, and some mammalian cell lines. Because of this, it has been proposed that the properties of MCT4 might be especially appropriate for export of lactate derived from glycolysis. MCT4 exhibits a lower affinity for most substrates and inhibitors than MCT1, with Km and Ki values some 5–10-fold higher. The high Km for pyruvate may be especially significant as this avoids loss of pyruvate from the cell which, were it to occur, would prevent removal of the reduced form of nicotinamide adenine dinucleotide (NADH) produced in glycolysis by reduction of pyruvate to lactate.

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