SLC14A2

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Solute carrier family 14 (urea transporter), member 2
Identifiers
Symbols SLC14A2 ; HUT2; UT-A2; UT2; UTA; UTR; hUT-A6
External IDs OMIM601611 MGI1351653 HomoloGene5183 GeneCards: SLC14A2 Gene
RNA expression pattern
PBB GE SLC14A2 208409 at tn.png
PBB GE SLC14A2 gnf1h08037 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8170 27411
Ensembl ENSG00000132874 ENSMUSG00000024552
UniProt Q15849 Q8R4T9
RefSeq (mRNA) NM_001242692 NM_001110273
RefSeq (protein) NP_001229621 NP_001103743
Location (UCSC) Chr 18:
42.79 – 43.26 Mb
Chr 18:
78.15 – 78.21 Mb
PubMed search [1] [2]

Urea transporter, kidney also known as urea transporter 2 (UT2) or solute carrier family 14 member 2 (SLC14A2) is a protein that in humans is encoded by the SLC14A2 gene.[1][2]

Function[edit]

In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A, and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene).[2] SLC14A2 and SLC14A1 constitute solute carrier family 14.

References[edit]

  1. ^ Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney". FEBS Lett 386 (2-3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. 
  2. ^ a b "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2". 

Further reading[edit]

  • Smith CP, Fenton RA (2007). "Genomic organization of the mammalian SLC14a2 urea transporter genes.". J. Membr. Biol. 212 (2): 109–17. doi:10.1007/s00232-006-0870-z. PMID 17264986. 
  • Olives B, Neau P, Bailly P, et al. (1995). "Cloning and functional expression of a urea transporter from human bone marrow cells.". J. Biol. Chem. 269 (50): 31649–52. PMID 7989337. 
  • Bradford AD, Terris JM, Ecelbarger CA, et al. (2001). "97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.". Am. J. Physiol. Renal Physiol. 281 (1): F133–43. PMID 11399654. 
  • Bagnasco SM, Peng T, Janech MG, et al. (2001). "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene.". Am. J. Physiol. Renal Physiol. 281 (3): F400–6. PMID 11502588. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Jung JY, Madsen KM, Han KH, et al. (2003). "Expression of urea transporters in potassium-depleted mouse kidney.". Am. J. Physiol. Renal Physiol. 285 (6): F1210–24. doi:10.1152/ajprenal.00111.2003. PMID 12952854. 
  • Smith CP, Potter EA, Fenton RA, Stewart GS (2004). "Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6.". Am. J. Physiol., Cell Physiol. 287 (4): C1087–93. doi:10.1152/ajpcell.00363.2003. PMID 15189812. 
  • Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas.". Placenta 27 (11-12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766. 
  • Hong X, Xing H, Yu Y, et al. (2007). "Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS.". Methods and findings in experimental and clinical pharmacology 29 (1): 3–10. doi:10.1358/mf.2007.29.1.1063490. PMID 17344938. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.