SLCO1B1

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Solute carrier organic anion transporter family, member 1B1
Identifiers
Symbols SLCO1B1 ; HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6
External IDs OMIM604843 HomoloGene74575 ChEMBL: 1697668 GeneCards: SLCO1B1 Gene
Orthologs
Species Human Mouse
Entrez 10599 n/a
Ensembl ENSG00000134538 n/a
UniProt Q9Y6L6 n/a
RefSeq (mRNA) NM_006446 n/a
RefSeq (protein) NP_006437 n/a
Location (UCSC) Chr 12:
21.28 – 21.39 Mb
n/a
PubMed search [1] n/a

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.[1][2] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.[3] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.[4]


See also[edit]

References[edit]

  1. ^ Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem 274 (24): 17159–63. doi:10.1074/jbc.274.24.17159. PMID 10358072. 
  2. ^ "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1". 
  3. ^ Carr, D. F.; o’Meara, H.; Jorgensen, A. L.; Campbell, J.; Hobbs, M.; McCann, G.; Van Staa, T.; Pirmohamed, M. (2013). "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics 94 (6): 695–701. doi:10.1038/clpt.2013.161. PMC 3831180. PMID 23942138.  edit
  4. ^ Huser, V.; Cimino, J. J. (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science 2013: 81. PMC 3814493. PMID 24303303.  edit

Further reading[edit]

  • Hsiang B, Zhu Y, Wang Z et al. (2000). "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. doi:10.1074/jbc.274.52.37161. PMID 10601278. 
  • König J, Cui Y, Nies AT, Keppler D (2000). "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. PMID 10644574. 
  • Rollinger-Holzinger I, Eibl B, Pauly M et al. (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. PMID 10706707. 
  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507. 
  • Tamai I, Nezu J, Uchino H et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595. 
  • Cui Y, König J, Leier I et al. (2001). "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. doi:10.1074/jbc.M004968200. PMID 11134001. 
  • Tirona RG, Leake BF, Merino G, Kim RB (2001). "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. doi:10.1074/jbc.M103792200. PMID 11477075. 
  • Jung D, Hagenbuch B, Gresh L et al. (2001). "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. doi:10.1074/jbc.M103988200. PMID 11483603. 
  • Nozawa T, Nakajima M, Tamai I et al. (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747. 
  • Michalski C, Cui Y, Nies AT et al. (2003). "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. doi:10.1074/jbc.M207735200. PMID 12196548. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. doi:10.1124/jpet.102.043026. PMID 12490595. 
  • Wang P, Kim RB, Chowdhury JR, Wolkoff AW (2003). "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. doi:10.1074/jbc.M301100200. PMID 12670950. 
  • Nishizato Y, Ieiri I, Suzuki H et al. (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. 
  • Niemi M, Schaeffeler E, Lang T et al. (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics 14 (7): 429–40. doi:10.1097/01.fpc.0000114750.08559.32. PMID 15226675. 
  • Huang MJ, Kua KE, Teng HC et al. (2005). "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464. 
  • Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. doi:10.1016/j.cbi.2004.08.008. PMID 15535988. 
  • Huang CS, Huang MJ, Lin MS et al. (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125. 
  • Katz DA, Carr R, Grimm DR et al. (2006). "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. doi:10.1016/j.clpt.2005.11.003. PMID 16513443. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.