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Solute carrier family 4 (anion exchanger), member 2
Symbols SLC4A2 ; AE2; BND3L; EPB3L1; HKB3; NBND3
External IDs OMIM109280 MGI109351 HomoloGene128699 IUPHAR: 905 GeneCards: SLC4A2 Gene
RNA expression pattern
PBB GE SLC4A2 202111 at tn.png
More reference expression data
Species Human Mouse
Entrez 6522 20535
Ensembl ENSG00000164889 ENSMUSG00000028962
UniProt P04920 P13808
RefSeq (mRNA) NM_001199692 NM_001253892
RefSeq (protein) NP_001186621 NP_001240821
Location (UCSC) Chr 7:
150.75 – 150.77 Mb
Chr 5:
24.42 – 24.44 Mb
PubMed search [1] [2]

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl/HCO3 exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3 transport in the gastrointestinal tract.[3] AE2 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]

AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]

See also[edit]


  1. ^ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol 30 (1): 34–57. PMID 8434259. 
  2. ^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". 
  3. ^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl/HCO3 exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461. 
  4. ^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081. 
  5. ^ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO3/Cl anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331. 
  6. ^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl/HCO3 exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575. 
  7. ^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596. 
  8. ^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.