SLC4A2

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Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
Identifiers
Symbols SLC4A2 ; AE2; BND3L; EPB3L1; HKB3; NBND3
External IDs OMIM109280 MGI109351 HomoloGene128699 GeneCards: SLC4A2 Gene
RNA expression pattern
PBB GE SLC4A2 202111 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6522 20535
Ensembl ENSG00000164889 ENSMUSG00000028962
UniProt P04920 P13808
RefSeq (mRNA) NM_001199692 NM_001253892
RefSeq (protein) NP_001186621 NP_001240821
Location (UCSC) Chr 7:
150.75 – 150.77 Mb
Chr 5:
24.42 – 24.44 Mb
PubMed search [1] [2]

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl/HCO3 exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3 transport in the gastrointestinal tract.[3] AE3 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]

AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]

See also[edit]

References[edit]

  1. ^ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol 30 (1): 34–57. PMID 8434259. 
  2. ^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". 
  3. ^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl/HCO3 exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461. 
  4. ^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081. 
  5. ^ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO3/Cl anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331. 
  6. ^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl/HCO3 exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575. 
  7. ^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596. 
  8. ^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.