GABA transporter 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Solute carrier family 6 (neurotransmitter transporter), member 1
External IDs OMIM137165 MGI95627 HomoloGene2290 ChEMBL: 1903 GeneCards: SLC6A1 Gene
RNA expression pattern
PBB GE SLC6A1 205152 at tn.png
More reference expression data
Species Human Mouse
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042 NM_178703
RefSeq (protein) NP_003033 NP_848818
Location (UCSC) Chr 3:
11.03 – 11.08 Mb
Chr 6:
114.28 – 114.32 Mb
PubMed search [1] [2]

GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]


GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3]


SLC6A1 has been shown to interact with STX1A.[4][5][6]

See also[edit]


  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094. 
  2. ^ "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1". 
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMC 2791799. PMID 19077666. 
  4. ^ Beckman, M L; Bernstein E M; Quick M W (August 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305. 
  5. ^ Quick, Michael W (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. doi:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023. 
  6. ^ Deken, S L; Beckman M L; Boos L; Quick M W (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. doi:10.1038/79939. ISSN 1097-6256. PMID 11017172. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.