Vesicular glutamate transporter 1

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Solute carrier family 17 (vesicular glutamate transporter), member 7
Identifiers
Symbols SLC17A7 ; BNPI; VGLUT1
External IDs OMIM605208 HomoloGene113454 GeneCards: SLC17A7 Gene
RNA expression pattern
PBB GE SLC17A7 204230 s at tn.png
PBB GE SLC17A7 204229 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57030 72961
Ensembl ENSG00000104888 ENSMUSG00000070570
UniProt Q9P2U7 Q3TXX4
RefSeq (mRNA) NM_020309 NM_182993
RefSeq (protein) NP_064705 NP_892038
Location (UCSC) Chr 19:
49.93 – 49.95 Mb
Chr 7:
45.16 – 45.18 Mb
PubMed search [1] [2]

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[1][2][3]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[3]

See also[edit]

References[edit]

  1. ^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. 
  2. ^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 74 (6): 2622–5. PMID 10820226. 
  3. ^ a b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.