Sodium–hydrogen antiporter 1

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Solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Protein SLC9A1 PDB 2bec.png
PDB rendering based on 2bec.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SLC9A1 ; APNH; NHE-1; NHE1; PPP1R143
External IDs OMIM107310 MGI102462 HomoloGene20660 ChEMBL: 2781 GeneCards: SLC9A1 Gene
RNA expression pattern
PBB GE SLC9A1 209453 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6548 20544
Ensembl ENSG00000090020 ENSMUSG00000028854
UniProt P19634 Q61165
RefSeq (mRNA) NM_003047 NM_016981
RefSeq (protein) NP_003038 NP_058677
Location (UCSC) Chr 1:
27.43 – 27.49 Mb
Chr 4:
133.37 – 133.42 Mb
PubMed search [1] [2]

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.[1]

Function[edit]

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.[2]

Interactions[edit]

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II[3] and CHP.[4][5][6]

References[edit]

  1. ^ Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968. 
  2. ^ Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238. 
  3. ^ Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. PMID 12138085. 
  4. ^ Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672. 
  5. ^ Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634. 
  6. ^ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981. 

Further reading[edit]