Excitatory amino-acid transporter 5

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Solute carrier family 1 (glutamate transporter), member 7
Symbols SLC1A7 ; AAAT; EAAT5
External IDs OMIM604471 MGI2444087 HomoloGene21327 ChEMBL: 4390 GeneCards: SLC1A7 Gene
Species Human Mouse
Entrez 6512 242607
Ensembl ENSG00000162383 ENSMUSG00000008932
UniProt O00341 Q8JZR4
RefSeq (mRNA) NM_006671 NM_146255
RefSeq (protein) NP_006662 NP_666367
Location (UCSC) Chr 1:
53.55 – 53.61 Mb
Chr 4:
107.97 – 108.01 Mb
PubMed search [1] [2]

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[1][2]

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[2]


Further reading[edit]

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412. 
  • Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648. 
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.