SLC30A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Solute carrier family 30 (zinc transporter), member 1
Identifiers
Symbols SLC30A1 ; ZNT1; ZRC1
External IDs OMIM609521 MGI1345281 HomoloGene6681 GeneCards: SLC30A1 Gene
Orthologs
Species Human Mouse
Entrez 7779 22782
Ensembl ENSG00000170385 ENSMUSG00000037434
UniProt Q9Y6M5 Q60738
RefSeq (mRNA) NM_021194 NM_009579
RefSeq (protein) NP_067017 NP_033605
Location (UCSC) Chr 1:
211.74 – 211.75 Mb
Chr 1:
191.91 – 191.91 Mb
PubMed search [1] [2]

Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]

Function[edit]

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3]

See also[edit]

References[edit]

  1. ^ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal 14 (4): 639–49. PMC 398127. PMID 7882967. 
  2. ^ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973. 
  3. ^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416. 

Further reading[edit]