SLC39A1

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Solute carrier family 39 (zinc transporter), member 1
Identifiers
Symbols SLC39A1 ; ZIP1; ZIRTL
External IDs OMIM604740 MGI1353474 HomoloGene40906 GeneCards: SLC39A1 Gene
RNA expression pattern
PBB GE SLC39A1 217778 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27173 30791
Ensembl ENSG00000143570 ENSMUSG00000052310
UniProt Q9NY26 Q9QZ03
RefSeq (mRNA) NM_001271957 NM_013901
RefSeq (protein) NP_001258886 NP_038929
Location (UCSC) Chr 1:
153.93 – 153.94 Mb
Chr 3:
90.25 – 90.25 Mb
PubMed search [1] [2]

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1] [2][3]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]


See also[edit]

References[edit]

  1. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721. 
  2. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536. 
  3. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1". 
  4. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911. 

Further reading[edit]