CD98

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solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
Symbol SLC3A2
Alt. symbols MDU1, 4T2HC, 4F2, NACAE, CD98
Entrez 6520
HUGO 11026
OMIM 158070
RefSeq NM_001013251
UniProt P08195
Other data
Locus Chr. 11 q12-q22
solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
Symbol SLC7A5
Alt. symbols LAT1, E16, D16S469E, MPE16, CD98
Entrez 8140
HUGO 11063
OMIM 600182
RefSeq NM_003486
UniProt Q01650
Other data
Locus Chr. 16 q24.3

CD98 is a glycoprotein[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.[3]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene [4]
  • CD98 light subunit protein encoded by the SLC7A5 gene[5]

See also[edit]

References[edit]

  1. ^ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135. 
  2. ^ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038. 
  3. ^ a b Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. doi:10.1073/pnas.96.21.12079. PMC 18415. PMID 10518579. 
  4. ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309. 
  5. ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310. 

External links[edit]