SLC11A1

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Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Identifiers
Symbols SLC11A1 ; LSH; NRAMP; NRAMP1
External IDs OMIM600266 MGI1345275 HomoloGene73884 GeneCards: SLC11A1 Gene
RNA expression pattern
PBB GE SLC11A1 210423 s at tn.png
PBB GE SLC11A1 210422 x at tn.png
PBB GE SLC11A1 217473 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6556 18173
Ensembl ENSG00000018280 ENSMUSG00000026177
UniProt P49279 P41251
RefSeq (mRNA) NM_000578 NM_013612
RefSeq (protein) NP_000569 NP_038640
Location (UCSC) Chr 2:
219.25 – 219.26 Mb
Chr 1:
74.38 – 74.39 Mb
PubMed search [1] [2]

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[1][2][3]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]

See also[edit]

References[edit]

  1. ^ Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (Dec 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". J Exp Med 180 (5): 1741–52. doi:10.1084/jem.180.5.1741. PMC 2191750. PMID 7964458. 
  2. ^ Kishi F (Dec 1994). "Isolation and characterization of human Nramp cDNA". Biochem. Biophys. Res. Commun. 204 (3): 1074–80. doi:10.1006/bbrc.1994.2572. PMID 7980580. 
  3. ^ a b "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1". 
  4. ^ Teras, IuKh.; Ryĭgas, EM.; Kazakova, II.; Ranne, KhP.; Trapido, LE. (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases].". Ter Arkh 52 (3): 123–5. PMID 7385031. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.