SLC25A14

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Solute carrier family 25 (mitochondrial carrier, brain), member 14
Identifiers
Symbols SLC25A14 ; BMCP1; UCP5
External IDs OMIM300242 MGI1330823 HomoloGene2937 GeneCards: SLC25A14 Gene
RNA expression pattern
PBB GE SLC25A14 204587 at tn.png
PBB GE SLC25A14 211855 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9016 20523
Ensembl ENSG00000102078 ENSMUSG00000031105
UniProt O95258 Q9Z2B2
RefSeq (mRNA) NM_003951 NM_001166450
RefSeq (protein) NP_003942 NP_001159922
Location (UCSC) Chr X:
129.47 – 129.51 Mb
Chr X:
48.62 – 48.66 Mb
PubMed search [1] [2]

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.[1][2]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.[2]

See also[edit]

References[edit]

  1. ^ Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, Gregoire F, Easlick J, Raimbault S, Levi-Meyrueis C, Miroux B, Collins S, Seldin M, Richard D, Warden C, Bouillaud F, Ricquier D (Jan 1999). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". J Biol Chem 273 (51): 34611–5. doi:10.1074/jbc.273.51.34611. PMID 9852133. 
  2. ^ a b "Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.