In 2009 there was a Phase III trial for knee pain due to osteoarthritis (OA).[2]
Another phase III trial for hip pain in OA [3] was halted in June 2010 when some patients needed hip replacement.[4]
Tanezumab is undergoing Phase II clinical trials for the treatment of various pain entities, including chronic low back pain, bone cancer pain, and interstitial cystitis.[5]
In march of 2012 the Anti-NGF Testing - FDA Committee voted in favor of a continuation of the development of nerve-blocking medications, as long as certain safety precautions were observed.
A phase III trial published in 2013 found tanezumab was superior to placebo for painful hip osteoarthritis.[6]