U-89843A

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U-89843A
Legal status
Legal status
  • In general: legal
Identifiers
  • 6,7-dimethyl-2,4-dipyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H23N5
Molar mass285.387 g/mol g·mol−1
3D model (JSmol)
  • CC1=CC2=C(N1C)N=C(N=C2N3CCCC3)N4CCCC4
  (verify)

U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.[1] It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.[2] It was developed by a team at Upjohn in the 1990s.[3]

References

  1. ^ Im, HK; Im, WB; Pregenzer, JF; Carter, DB; Hamilton, BJ (1995). "U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors". The Journal of Pharmacology and Experimental Therapeutics. 275 (3): 1390–5. PMID 8531107.
  2. ^ Bundy, GL; Ayer, DE; Banitt, LS; Belonga, KL; Mizsak, SA; Palmer, JR; Tustin, JM; Chin, JE; et al. (1995). "Synthesis of novel 2,4-diaminopyrrolo-2,3-dpyrimidines with antioxidant, neuroprotective, and antiasthma activity". Journal of Medical Chemistry. 38 (21): 4161–3. doi:10.1021/jm00021a004. PMID 7473542.
  3. ^ US Patent 5502187 Pharmaceutically active bicyclic-heterocyclic amines


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