Synaptotagmins

Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B.

There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.

Members

• Synaptotagmin 1 (SYT1)
• Synaptotagmin 2 (SYT2)
• Synaptotagmin 3 (SYT3)
• Synaptotagmin 4 (SYT4)
• Synaptotagmin 5 (SYT5)
• Synaptotagmin 6 (SYT6)
• Synaptotagmin 7 (SYT7)
• Synaptotagmin 8 (SYT8)
• Synaptotagmin 9 (SYT9)
• Synaptotagmin 10 (SYT10)
• Synaptotagmin 11 (SYT11)
• Synaptotagmin 12 (SYT12)
• Synaptotagmin 13 (SYT13)
• Synaptotagmin 14 (SYT14)
• Synaptotagmin 15 (SYT15)

External links

• UMich Orientation of Proteins in Membranes families/superfamily-47 - Orientations of C2 domains in the lipid bilayer
• Synaptotagmins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)