N1-Methyl-lysergic acid diethylamide

N1-Methyl-lysergic acid diethylamide
Clinical data
Other names	MLD-41, N1- Methyl- Lysergic Acid Diethylamide
Routes of; administration	Oral
Pharmacokinetic data
Metabolism	hepatic
Excretion	renal
Identifiers
	IUPAC name (8β)-N,N-Diethyl-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide;
CAS Number	4238-85-1 ;
PubChem CID	165200;
ChemSpider	144824 ;
CompTox Dashboard (EPA)	DTXSID00895034 ;
Chemical and physical data
Formula	C21H27N3O
Molar mass	337.467 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(CC)CC)[C@@H]3/C=C2/c4cccc1c4c(cn1C)C[C@H]2N(C3)C;
	InChI InChI=1S/C21H27N3O/c1-5-24(6-2)21(25)15-10-17-16-8-7-9-18-20(16)14(12-22(18)3)11-19(17)23(4)13-15/h7-10,12,15,19H,5-6,11,13H2,1-4H3/t15-,19-/m1/s1 ; Key:VQZYKSWQIQANKB-DNVCBOLYSA-N ;
	(verify)

N1-Methyl-lysergic acid diethylamide (MLD-41) is a derivative of LSD that has about one-third the psychoactive effects. It has been studied in cross-tolerance of LSD.^[1]

Metabolism of other 1-methylated-ergoloids to their secondary amine derivatives has been frequently noted in mammals.^[2]

References

^ https://www.tandfonline.com/doi/abs/10.1080/00223980.1960.9916396?journalCode=vjrl20
^ Müller-Schweinitzer and Tapparelli (1986). Methylergometrine, an active metabolite of methysergide. Cephalalgia. 6: 35-41.

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[1] ttps://www.tandfonline.com/doi/abs/10.1080/00223980.1960.9916396?journalCode=vjrl20

[2] Müller-Schweinitzer and Tapparelli (1986). Methylergometrine, an active metabolite of methysergide. Cephalalgia. 6: 35-41.

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