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HU-211 structure.png
Clinical data
ATC code none
CAS Number 112924-45-5 YesY
PubChem (CID) 107778
ChemSpider 96934 N
UNII R6VT8U5372 YesY
ECHA InfoCard 100.201.022
Chemical and physical data
Formula C25H38O3
Molar mass 386.567 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Dexanabinol (HU-211 or ETS2101[1]) is a synthetic cannabinoid derivative in development by e-Therapeutics plc. It is the "unnatural" enantiomer of the potent cannabinoid agonist HU-210.[2] Unlike other cannabinoid derivatives, HU-211 does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist effects.[3] It therefore does not produce cannabis-like effects, but is anticonvulsant and neuroprotective, and is widely used in scientific research as well as currently being studied for applications such as treating head injury, stroke, or cancer.[4][5][6] It was shown to be safe in clinical trials[7] and is currently undergoing Phase I trials for the treatment of brain cancer[8] and advanced solid tumors.[9]

Clinical Trials[edit]

Dexanabinol has been studied in IV administration and oral dosing.[10] e-Therapeutics is evaluating the compound in clinical trials for brain and solid cancers.[11] Phase II studies are planned based on the results of the current trials.

A phase 1b study for hepatocellular carcinoma and pancreatic cancer was started in 2015.[12]

Legal status[edit]

HU-211 is not listed in the schedules set out by the United Nations' Single Convention on Narcotic Drugs from 1961 nor their Convention on Psychotropic Substances from 1971.[13]

United States[edit]

HU-211 is not listed in the list of scheduled controlled substances in the USA.[14] It is therefore not scheduled at the federal level in the United States, but it is possible that HU-211 could legally be considered an analog of Delta-8-THC and sales or possession could potentially be prosecuted under the Federal Analogue Act.[15]


HU-211 is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[16] It is listed twice under the hallucinogic substances subcategory:


  1. ^ e-therapeutics Clinical Development Pipeline
  2. ^ Pop E (September 2000). "Nonpsychotropic synthetic cannabinoids". Current Pharmaceutical Design. 6 (13): 1347–60. doi:10.2174/1381612003399446. PMID 10903397. 
  3. ^ Feigenbaum JJ; et al. (December 1989). "Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker". Proceedings of the National Academy of Sciences of the United States of America. 86 (23): 9584–7. doi:10.1073/pnas.86.23.9584. PMC 298542Freely accessible. PMID 2556719. 
  4. ^ Biegon A; Joseph AB (August 1995). "Development of HU-211 as a neuroprotectant for ischemic brain damage". Neurological Research. 17 (4): 275–80. PMID 7477742. 
  5. ^ Darlington CL (October 2003). "Dexanabinol: a novel cannabinoid with neuroprotective properties". IDrugs : the Investigational Drugs Journal. 6 (10): 976–9. PMID 14534855. 
  6. ^ Vink R; Nimmo AJ (January 2009). "Multifunctional drugs for head injury". Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. 6 (1): 28–42. doi:10.1016/j.nurt.2008.10.036. PMID 19110197. 
  7. ^ Maas AI; et al. (January 2006). "Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial". Lancet Neurol. 5 (1): 38–45. doi:10.1016/S1474-4422(05)70253-2. PMID 16361021. 
  8. ^ University of California, San Diego "Synthetic Cannabinoid May Be Used as Brain Cancer Treatment". (28 September 2012) Laboratory Equipment. Retrieved 28 September 2012.
  9. ^ "A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours". NIH. January 26, 2015. 
  10. ^ "e-Therapeutics Reports Progress in ETS2101 Phase 1a and Oral Dosing Studies" (PDF). 18 December 2014. 
  11. ^ "Clinical Development Pipeline". Retrieved Feb 5, 2015. 
  12. ^ "A Study of Dexanabinol in Combination With Chemotherapy in Patients With Advanced Tumours - Full Text View -". Retrieved 2015-09-18. 
  13. ^ UN International Drug Control Conventions
  14. ^ §1308.11 Schedule I.
  15. ^ Erowid Analog Law Vault : Federal Controlled Substance Analogue Act Summary
  16. ^ Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL