2,5-Dimethoxy-4-isopropylamphetamine (also known as DOiP and DOiPr) is a psychedelicdrug of the phenethylamine and amphetaminechemical classes. It was first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved). Shulgin described DOiPR as being at least an order of magnitude weaker than DOPr, with doses of 20–30 mg required to produce valid changes in mental state.
Very little data exists about the pharmacological properties, metabolism, and toxicity of DOiPR.
^Richard A. Glennon; Mark R. Seggel (November 1989). Interaction of phenylisopropylamines with central 5-HT2 receptors. Analysis by quantitative structure-activity relationships. ACS Symposium Series. 413. pp. 264–280. doi:10.1021/bk-1989-0413.ch018. ISBN978-0-8412-1702-7.
^Mark R. Seggel; M. Y. Yousif; Robert A. Lyon; Milt Titeler; Bryan L. Roth; Eva A. Suba; Richard A. Glennon (March 1990). "A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors". Journal of Medicinal Chemistry. 33 (3): 1032–1036. doi:10.1021/jm00165a023. PMID2308135.
^F. A. B. Aldous; B. C. Barrass; K. Brewster; D. A. Buxton; D. M. Green; R. M. Pinder; P. Rich; M. Skeels; K. J. Tutt (October 1974). "Structure-activity relations in psychotomimetic phenylalkylamines". Journal of Medicinal Chemistry. 17 (10): 1100–1111. doi:10.1021/jm00256a016. PMID4418757.