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Folate transporter 1

From Wikipedia, the free encyclopedia
SLC19A1
Identifiers
AliasesSLC19A1, CHMD, FOLT, IFC1, REFC, RFC1, solute carrier family 19 member 1, IFC-1, RFC, hRFC, RFT-1, hMEGAF
External IDsOMIM: 600424; MGI: 103182; HomoloGene: 57139; GeneCards: SLC19A1; OMA:SLC19A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199271
NM_031196

RefSeq (protein)

NP_001186200
NP_112473

Location (UCSC)Chr 21: 45.49 – 45.57 MbChr 10: 77.03 – 77.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.[5]

Function

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Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[6] SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP.[7]

Clinical significance

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Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.[8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

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  • Reduced folate carrier 1
  • Intestinal folate carrier 1

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173638Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001436Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, Tassone F, Blouin JL, Scott HS, Antonarakis SE, Créau N, Brahe C (April 1998). "Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3". Genomics. 49 (1): 1–13. doi:10.1006/geno.1997.5185. PMID 9570943.
  6. ^ "Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1".
  7. ^ Ritchie, C; Cordova, AF; Hess, GT; Bassik, MC; Li, L (25 July 2019). "SLC19A1 Is an Importer of the Immunotransmitter cGAMP". Molecular Cell. 75 (2): 372–381.e5. doi:10.1016/j.molcel.2019.05.006. PMC 6711396. PMID 31126740.
  8. ^ Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS (September 2009). "The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women". Annals of Human Genetics. 73 (Pt 5): 484–91. doi:10.1111/j.1469-1809.2009.00529.x. PMC 2812009. PMID 19650776.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.