Interleukin-21 receptor

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IL21R
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL21R, CD360, NILR, interleukin 21 receptor
External IDs MGI: 1890475 HomoloGene: 11040 GeneCards: 50615
RNA expression pattern
PBB GE IL21R 219971 at tn.png

PBB GE IL21R 221658 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021798
NM_181078
NM_181079

NM_021887

RefSeq (protein)

NP_068570.1
NP_851564.1
NP_851565.4

NP_068687.1

Location (UCSC) Chr 16: 27.4 – 27.45 Mb Chr 7: 125.6 – 125.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.[3]

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.[3]

References[edit]

Further reading[edit]