Putative sodium-coupled neutral amino acid transporter 10

SLC38A10
Identifiers
Aliases	SLC38A10, PP1744, solute carrier family 38 member 10
External IDs	OMIM: 616525; MGI: 1919305; HomoloGene: 41556; GeneCards: SLC38A10; OMA:SLC38A10 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,295,547 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,042,172 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; body of pancreas; ; right lobe of liver; ; right lobe of thyroid gland; ; mucosa of transverse colon; ; apex of heart; ; right uterine tube; ; right coronary artery; ; left lobe of thyroid gland; ; granulocyte;
	Top expressed in
	motor neuron; ; fossa; ; calvaria; ; aortic valve; ; ascending aorta; ; vestibular membrane of cochlear duct; ; Paneth cell; ; condyle; ; external carotid artery; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; Golgi apparatus;
Biological process	amino acid transmembrane transport; bone development; ion transport; amino acid transport; sodium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	124565
	72055
	ENSG00000157637
	ENSMUSG00000061306
	Q9HBR0
	Q5I012
	NM_001037984; NM_138570
NM_001164798; NM_001164799; NM_001164800; NM_001164801; NM_001164802;
	NM_024249; NM_001361696; NM_001361697; NM_001361698; NM_001361699
	NP_001033073; NP_612637
NP_001158270; NP_001158271; NP_001158272; NP_001158273; NP_001158274;
	NP_077211; NP_001348625; NP_001348626; NP_001348627; NP_001348628
	Wikidata
View/Edit Human	View/Edit Mouse

Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10,^[5] is a protein that in humans is encoded by the SLC38A10 gene.^[6]

Cellular localization

Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles.^[7]

Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.^[8]

Cancer

A SLC38A family member has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[9] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157637 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "SLC38A10 - Function". www.nextprot.org. Retrieved 2021-11-29.
^ "Entrez Gene: solute carrier family 38, member 10". Retrieved 2011-08-30.
^ Tripathi R, Hosseini K, Arapi V, Fredriksson R, Bagchi S (December 2019). "SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis". International Journal of Molecular Sciences. 20 (24): 6265. doi:10.3390/ijms20246265. PMC 6940841. PMID 31842320.
^ Tripathi R, Aggarwal T, Fredriksson R (2021). "SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity". Frontiers in Molecular Biosciences. 8: 671865. doi:10.3389/fmolb.2021.671865. ISSN 2296-889X. PMC 8133219. PMID 34026845.
^ ^a ^b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, et al. (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". Journal of Cellular Physiology. 230 (4): 806–12. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Cellular localization

Cancer

References

Further reading