Sodium–hydrogen antiporter 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Protein SLC9A1 PDB 2bec.png
PDB rendering based on 2bec.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SLC9A1 ; APNH; LIKNS; NHE-1; NHE1; PPP1R143
External IDs OMIM107310 MGI102462 HomoloGene20660 ChEMBL: 2781 GeneCards: SLC9A1 Gene
RNA expression pattern
PBB GE SLC9A1 209453 at tn.png
More reference expression data
Species Human Mouse
Entrez 6548 20544
Ensembl ENSG00000090020 ENSMUSG00000028854
UniProt P19634 Q61165
RefSeq (mRNA) NM_003047 NM_016981
RefSeq (protein) NP_003038 NP_058677
Location (UCSC) Chr 1:
27.1 – 27.17 Mb
Chr 4:
133.37 – 133.42 Mb
PubMed search [1] [2]

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.[1]


The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.[2]


Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II[3] and CHP.[4][5][6] It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.[7]


  1. ^ Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968. 
  2. ^ Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238. 
  3. ^ Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. PMID 12138085. 
  4. ^ Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672. 
  5. ^ Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634. 
  6. ^ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981. 
  7. ^ Spreitzer, Helmut (26 May 2015). "Rimeporide". Österreichische Apothekerzeitung (in German) 69 (11): 12. 

Further reading[edit]