Ferroportin: Difference between revisions

SLC40A1
Identifiers
Aliases	SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
External IDs	OMIM: 604653 MGI: 1315204 HomoloGene: 40959 GeneCards: SLC40A1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	189,583,758 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	45,965,683 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; jejunal mucosa; ; germinal epithelium; ; trabecular bone; ; palpebral conjunctiva; ; superficial temporal artery; ; duodenum; ; caput epididymis; ; parietal pleura; ; gallbladder;
	Top expressed in
	medullary collecting duct; ; duodenum; ; spleen; ; left colon; ; liver; ; ileum; ; yolk sac; ; left lobe of liver; ; extraocular muscle; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	ferrous iron transmembrane transporter activity; iron ion transmembrane transporter activity; peptide hormone binding; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; synaptic vesicle; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; basolateral plasma membrane; nucleoplasm; cytosol;
Biological process	iron ion transmembrane transport; lymphocyte homeostasis; spleen trabecula formation; iron ion homeostasis; negative regulation of apoptotic process; ion transport; spleen development; multicellular organismal iron ion homeostasis; iron ion transport; endothelium development; iron ion export across plasma membrane; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; regulation of transcription from RNA polymerase II promoter in response to iron;
	Sources:Amigo / QuickGO
Orthologs
	30061
	53945
	ENSG00000138449
	ENSMUSG00000025993
	Q9NP59
	Q9JHI9
	NM_014585
	NM_016917
	NP_055400
	NP_058613
	Wikidata
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Revision as of 17:34, 19 January 2008

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Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron, including:

Enterocytes in the duodenum
Hepatocytes
Macrophages of the reticuloendothelial system.

Recent research suggests that ferroportin is the key molecule regulated by hepcidin, the apparent "master regulator" of human iron metabolism.

Clinical significance

Ferroportin can be associated with African iron overload.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138449 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025993 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

External links

ferroportin1+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138449 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025993 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{protein
+{{PBB_Controls
-|Name=solute carrier family 40 (iron-regulated transporter), member 1
+| update_page = yes
-|caption=
+| require_manual_inspection = no
-|image=
+| update_protein_box = yes
-|width=
+| update_summary = no
-|HGNCid=10909
+| update_citations = yes
-|Symbol=SLC40A1
+}}
-|AltSymbols=SLC11A3 FPN1
-|EntrezGene=30061
+<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-|OMIM=604653
+{{GNF_Protein_box
-|RefSeq=NM_014585
+ | image =
-|UniProt=Q9NP59
+ | image_source =
-|PDB=
+ | PDB =
-|ECnumber=
+ | Name = Solute carrier family 40 (iron-regulated transporter), member 1
-|Chromosome=2
+ | HGNCid = 10909
-|Arm=q
+ | Symbol = SLC40A1
-|Band=32
+ | AltSymbols =; FPN1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3
-|LocusSupplementaryData=
+ | OMIM = 604653
+ | ECnumber =
+ | Homologene = 40959
+ | MGIid = 1315204
+ | Function = {{GNF_GO|id=GO:0005381 |text = iron ion transmembrane transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}}
+ | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}}
+ | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
+ | Orthologs = {{GNF_Ortholog_box
+    | Hs_EntrezGene = 30061
+    | Hs_Ensembl = ENSG00000138449
+    | Hs_RefseqProtein = NP_055400
+    | Hs_RefseqmRNA = NM_014585
+    | Hs_GenLoc_db =
+    | Hs_GenLoc_chr = 2
+    | Hs_GenLoc_start = 190133563
+    | Hs_GenLoc_end = 190153858
+    | Hs_Uniprot = Q9NP59
+    | Mm_EntrezGene = 53945
+    | Mm_Ensembl = ENSMUSG00000025993
+    | Mm_RefseqmRNA = NM_016917
+    | Mm_RefseqProtein = NP_058613
+    | Mm_GenLoc_db =
+    | Mm_GenLoc_chr = 1
+    | Mm_GenLoc_start = 45852630
+    | Mm_GenLoc_end = 45870079
+    | Mm_Uniprot = Q3TJ33
+  }}
 }}
 '''Ferroportin''' is a [[transmembrane protein]] that transports [[iron]] from the inside of a [[cell (biology)|cell]] to the outside of it. It is found on the surface of cells that store or transport iron, including:
@@ Line 28: / Line 55: @@
 ==Clinical significance==
 Ferroportin can be associated with [[African iron overload]].
+==References==
+{{reflist}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | author=Pietrangelo A |title=The ferroportin disease. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 131-8 |year= 2004 |pmid= 14757427 |doi=  }}
+*{{cite journal  | author=Robson KJ, Merryweather-Clarke AT, Cadet E, ''et al.'' |title=Recent advances in understanding haemochromatosis: a transition state. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 721-30 |year= 2005 |pmid= 15466004 |doi= 10.1136/jmg.2004.020644 }}
+*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  | author=Donovan A, Brownlie A, Zhou Y, ''et al.'' |title=Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. |journal=Nature |volume=403 |issue= 6771 |pages= 776-81 |year= 2000 |pmid= 10693807 |doi= 10.1038/35001596 }}
+*{{cite journal  | author=Abboud S, Haile DJ |title=A novel mammalian iron-regulated protein involved in intracellular iron metabolism. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19906-12 |year= 2000 |pmid= 10747949 |doi= 10.1074/jbc.M000713200 }}
+*{{cite journal  | author=Haile DJ |title=Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 328-9 |year= 2000 |pmid= 10828623 |doi=  }}
+*{{cite journal  | author=McKie AT, Marciani P, Rolfs A, ''et al.'' |title=A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. |journal=Mol. Cell |volume=5 |issue= 2 |pages= 299-309 |year= 2000 |pmid= 10882071 |doi=  }}
+*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
+*{{cite journal  | author=Njajou OT, Vaessen N, Joosse M, ''et al.'' |title=A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. |journal=Nat. Genet. |volume=28 |issue= 3 |pages= 213-4 |year= 2001 |pmid= 11431687 |doi= 10.1038/90038 }}
+*{{cite journal  | author=Montosi G, Donovan A, Totaro A, ''et al.'' |title=Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. |journal=J. Clin. Invest. |volume=108 |issue= 4 |pages= 619-23 |year= 2001 |pmid= 11518736 |doi=  }}
+*{{cite journal  | author=Press RD |title=Hemochromatosis caused by mutations in the iron-regulatory proteins ferroportin and H ferritin. |journal=Mol. Diagn. |volume=6 |issue= 4 |pages= 347 |year= 2002 |pmid= 11774199 |doi=  }}
+*{{cite journal  | author=Lee PL, Gelbart T, West C, ''et al.'' |title=A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 783-802 |year= 2003 |pmid= 11783942 |doi= 10.1006/bcmd.2001.0445 }}
+*{{cite journal  | author=Rolfs A, Bonkovsky HL, Kohlroser JG, ''et al.'' |title=Intestinal expression of genes involved in iron absorption in humans. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 4 |pages= G598-607 |year= 2002 |pmid= 11897618 |doi= 10.1152/ajpgi.00371.2001 }}
+*{{cite journal  | author=Thomas C, Oates PS |title=IEC-6 cells are an appropriate model of intestinal iron absorption in rats. |journal=J. Nutr. |volume=132 |issue= 4 |pages= 680-7 |year= 2002 |pmid= 11925460 |doi=  }}
+*{{cite journal  | author=Wallace DF, Pedersen P, Dixon JL, ''et al.'' |title=Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. |journal=Blood |volume=100 |issue= 2 |pages= 692-4 |year= 2002 |pmid= 12091366 |doi=  }}
+*{{cite journal  | author=Devalia V, Carter K, Walker AP, ''et al.'' |title=Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). |journal=Blood |volume=100 |issue= 2 |pages= 695-7 |year= 2002 |pmid= 12091367 |doi= 10.1182/blood-2001-11-0132 }}
+*{{cite journal  | author=Roetto A, Merryweather-Clarke AT, Daraio F, ''et al.'' |title=A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4. |journal=Blood |volume=100 |issue= 2 |pages= 733-4 |year= 2002 |pmid= 12123233 |doi=  }}
+}}
+{{refend}}
 ==External links==
 * {{MeshName|ferroportin1+protein}}
+{{membrane-protein-stub}}
 {{Membrane transport proteins}}
 [[Category:Hematology]]
-[[Category:Transmembrane proteins]]
 [[Category:Metabolism]]
+[[Category:Transport proteins]]
+[[Category:Transmembrane proteins]]
-{{membrane-protein-stub}}
 [[de:Ferroportin]]