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*{{cite journal |author=Matalon ST, Drucker L, Fishman A, ''et al.'' |title=The Role of heat shock protein 27 in extravillous trophoblast differentiation. |journal=J. Cell. Biochem. |volume=103 |issue= 3 |pages= 719-29 |year= 2008 |pmid= 17661346 |doi= 10.1002/jcb.21476 }}
*{{cite journal |author=Matalon ST, Drucker L, Fishman A, ''et al.'' |title=The Role of heat shock protein 27 in extravillous trophoblast differentiation. |journal=J. Cell. Biochem. |volume=103 |issue= 3 |pages= 719-29 |year= 2008 |pmid= 17661346 |doi= 10.1002/jcb.21476 }}
*{{cite journal |author=Begley GS, Horvath AR, Taylor JC, Higgins CF |title=Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. |journal=Mol. Immunol. |volume=42 |issue= 1 |pages= 137-41 |year= 2005 |pmid= 15488952 |doi= 10.1016/j.molimm.2004.07.005 }}
*{{cite journal |author=Begley GS, Horvath AR, Taylor JC, Higgins CF |title=Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. |journal=Mol. Immunol. |volume=42 |issue= 1 |pages= 137-41 |year= 2005 |pmid= 15488952 |doi= 10.1016/j.molimm.2004.07.005 }}
*{{cite journal |author=Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF|title=A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases.|journal=Am J Hum Genet.|volume=|issue=|pages=|year=2010|pmid=20950786|doi=10.1016/j.ajhg.2010.09.014 }}
*{{cite journal |author=Fukunaga-Kalabis M, Martinez G, Nguyen TK, Kim D, Santiago-Walker A, Roesch A, Herlyn M. |title=Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. |journal=Oncogene |volume= |issue= |pages= |year= 2010|pmid= 20729912|doi=10.1038/onc.2010.350 |url= http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2010350a.html}}
*{{cite journal |author= Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST.|title= Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance.|journal= |volume= |issue= |pages= |year=2010 |pmid= 20682318|doi= 10.1053/j.gastro.2010.07.049|url=http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFX-50NYWT2-7&_user=209690&_coverDate=08%2F02%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000014438&_version=1&_urlVersion=0&_userid=209690&md5=96beb13c8b38d1b97064d2eb75ad779a&searchtype=a }}
*{{cite journal |author=Yang JY, Ha SA, Yang YS, Kim JW. |title= p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance.|journal= BMC Cancer|volume=10 |issue= |pages=388 |year=2010 |pmid=20649952 |doi=10.1186/1471-2407-10-388 |url= http://www.biomedcentral.com.ezp-prod1.hul.harvard.edu/1471-2407/10/388}}
*{{cite journal |author=Sharma BK, Manglik V, Elias EG. |title=Immuno-expression of human melanoma stem cell markers in tissues at different stages of the disease. |journal=J Surg Res. |volume=163 |issue= 1|pages= e11-5|year=2010 |pmid=20638684 |doi= doi:10.1016/j.jss.2010.03.043|url=http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WM6-4YVFJDS-2&_user=209690&_coverDate=09%2F30%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000014438&_version=1&_urlVersion=0&_userid=209690&md5=12986b15acf0aef9f8310bc72f1ed765&searchtype=a }}
*{{cite journal |author=Gazzaniga P, Cigna E, Panasiti V, Devirgiliis V, Bottoni U, Vincenzi B, Nicolazzo C, Petracca A, Gradilone A. |title= CD133 and ABCB5 as stem cell markers on sentinel lymph node from melanoma patients.|journal=Eur J Surg Oncol. |volume= |issue= |pages= |year= |pmid=20573479 |doi=10.1016/j.ejso.2010.05.001 |url= http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WF4-50CD20B-1&_user=209690&_coverDate=06%2F23%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000014438&_version=1&_urlVersion=0&_userid=209690&md5=6dd264d9959f7cf2d0c56f2f4ff80fd5&searchtype=a}}
*{{cite journal |author= Ma J, Frank MH.|title= Tumor initiation in human malignant melanoma and potential cancer therapies.|journal= Anticancer Agents Med Chem. |volume=10 |issue=2 |pages=131-6 |year=2010 |pmid=20184545 |doi= ISSN: 1871-5206 |url=http://www.benthamdirect.org/pages/b_viewarticle.php?3158333 }}
*{{cite journal |author= |title= |journal= |volume= |issue= |pages= |year= |pmid= |doi= |url= }}
*{{cite journal |author= |title= |journal= |volume= |issue= |pages= |year= |pmid= |doi= |url= }}
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Revision as of 20:12, 19 October 2010

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ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a protein that in humans is encoded by the ABCB5 gene.[1][2] ABCB5 is a ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.[3][4]

ABCB5 regulates skin progenitor cell fusion and mediates chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma.[5]

References

  1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh MH, Frank MH (2003). "Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter". J. Biol. Chem. 278 (47): 47156–65. doi:10.1074/jbc.M308700200. PMID 12960149. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  3. ^ Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM (2005). "Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes". Pigment Cell Res. 18 (2): 102–12. doi:10.1111/j.1600-0749.2005.00214.x. PMID 15760339. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH (2005). "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma". Cancer Res. 65 (10): 4320–33. doi:10.1158/0008-5472.CAN-04-3327. PMID 15899824. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Schatton, Tobias (Jan. 2008). "Identification of cells initiating human melanomas". Nature. 451 (7176): 345–9. doi:doi:10.1038/nature06489. PMID 18202660. {{cite journal}}: Check |doi= value (help); Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

Further reading

External links