This is an old revision of this page, as edited by Rjwilmsi(talk | contribs) at 15:44, 25 February 2016(→top: Journal cites: fix journal name, using AWB (11927)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 15:44, 25 February 2016 by Rjwilmsi(talk | contribs)(→top: Journal cites: fix journal name, using AWB (11927))
A-84543 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It is widely used in scientific research into the structure and function of this receptor subtype and has been the lead compound for the development of a large family of related derivatives.[1][2][2][3][4]
References
^Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y.; Donnelly-Roberts, D.; Anderson, D. J.; Sullivan, J. P.; Williams, M.; Arneric, S. P.; Holladay, M. W. (1996). "Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors". Journal of Medicinal Chemistry. 39 (4): 817–825. doi:10.1021/jm9506884. PMID8632405.
^ abLin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L.; Anderson, D. J.; Campbell, J. E.; Sullivan, J. P.; Arneric, S. P.; Holladay, M. W. (1998). "Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist". Bioorganic & Medicinal Chemistry Letters. 8 (3): 249–254. doi:10.1016/S0960-894X(98)00019-5. PMID9871663.
^Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). "Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits". Journal of Medicinal Chemistry. 48 (6): 1721–1724. doi:10.1021/jm0492406. PMID15771418.
^Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). "Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)". The Journal of Organic Chemistry. 72 (8): 3112–3115. doi:10.1021/jo0700732. PMID17371077.