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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category)
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Sodium-dependent neutral amino acid transporter B(0)AT2''' is a [[protein]] that in humans is encoded by the ''SLC6A15'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 6 (neutral amino acid transporter)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55117| accessdate = }}</ref>
'''Sodium-dependent neutral amino acid transporter B(0)AT2''' is a [[protein]] that in humans is encoded by the ''SLC6A15'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: solute carrier family 6 (neutral amino acid transporter)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55117}}</ref>


== Function ==
== Function ==
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{{refbegin|33em}}
{{refbegin|33em}}
* {{cite journal | vauthors = Bröer A, Tietze N, Kowalczuk S, Chubb S, Munzinger M, Bak LK, Bröer S | title = The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2) | journal = The Biochemical Journal | volume = 393 | issue = Pt 1 | pages = 421–30 | date = Jan 2006 | pmid = 16185194 | pmc = 1383701 | doi = 10.1042/BJ20051273 }}
* {{cite journal | vauthors = Bröer A, Tietze N, Kowalczuk S, Chubb S, Munzinger M, Bak LK, Bröer S | title = The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2) | journal = The Biochemical Journal | volume = 393 | issue = Pt 1 | pages = 421–30 | date = Jan 2006 | pmid = 16185194 | pmc = 1383701 | doi = 10.1042/BJ20051273 }}
* {{cite journal | vauthors = Zaia KA, Reimer RJ | title = Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport | journal = The Journal of Biological Chemistry | volume = 284 | issue = 13 | pages = 8439–48 | date = Mar 2009 | pmid = 19147495 | pmc = 2659202 | doi = 10.1074/jbc.M806407200 }}
* {{cite journal | vauthors = Zaia KA, Reimer RJ | title = Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport | journal = The Journal of Biological Chemistry | volume = 284 | issue = 13 | pages = 8439–48 | date = Mar 2009 | pmid = 19147495 | pmc = 2659202 | doi = 10.1074/jbc.M806407200 | doi-access = free }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
* {{cite journal | vauthors = Bröer S | title = Amino acid transport across mammalian intestinal and renal epithelia | journal = Physiological Reviews | volume = 88 | issue = 1 | pages = 249–86 | date = Jan 2008 | pmid = 18195088 | doi = 10.1152/physrev.00018.2006 }}
* {{cite journal | vauthors = Bröer S | title = Amino acid transport across mammalian intestinal and renal epithelia | journal = Physiological Reviews | volume = 88 | issue = 1 | pages = 249–86 | date = Jan 2008 | pmid = 18195088 | doi = 10.1152/physrev.00018.2006 }}
* {{cite journal | vauthors = Takanaga H, Mackenzie B, Peng JB, Hediger MA | title = Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain | journal = Biochemical and Biophysical Research Communications | volume = 337 | issue = 3 | pages = 892–900 | date = Nov 2005 | pmid = 16226721 | doi = 10.1016/j.bbrc.2005.09.128 }}
* {{cite journal | vauthors = Takanaga H, Mackenzie B, Peng JB, Hediger MA | title = Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain | journal = Biochemical and Biophysical Research Communications | volume = 337 | issue = 3 | pages = 892–900 | date = Nov 2005 | pmid = 16226721 | doi = 10.1016/j.bbrc.2005.09.128 }}
* {{cite journal | vauthors = Masson J, Sagné C, Hamon M, El Mestikawy S | title = Neurotransmitter transporters in the central nervous system | journal = Pharmacological Reviews | volume = 51 | issue = 3 | pages = 439–64 | date = Sep 1999 | pmid = 10471414 | doi = }}
* {{cite journal | vauthors = Masson J, Sagné C, Hamon M, El Mestikawy S | title = Neurotransmitter transporters in the central nervous system | journal = Pharmacological Reviews | volume = 51 | issue = 3 | pages = 439–64 | date = Sep 1999 | pmid = 10471414 }}
{{refend}}
{{refend}}


Latest revision as of 01:12, 4 March 2023

SLC6A15
Identifiers
AliasesSLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDsOMIM: 607971; MGI: 2143484; HomoloGene: 18163; GeneCards: SLC6A15; OMA:SLC6A15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

55117

103098

Ensembl

ENSG00000072041

ENSMUSG00000019894

UniProt

Q9H2J7

Q8BG16

RefSeq (mRNA)

NM_001146335
NM_018057
NM_182767

NM_001252330
NM_175328
NM_001358821

RefSeq (protein)

NP_001139807
NP_060527
NP_877499

NP_001239259
NP_780537
NP_001345750

Location (UCSC)Chr 12: 84.86 – 84.91 MbChr 10: 103.2 – 103.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.[5]

Function

[edit]

SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[6]

Clinical relevance

[edit]

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072041 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019894 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
  6. ^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.
  7. ^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612.

Further reading

[edit]


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